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Sigma-Aldrich
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021-61415566 800-8193336 |
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Product Name:Monoclonal Anti-Lamin A/C antibody produced in mouse
Purity:clone 4C11, purified from hybridoma cell culture Package:200UL Remarks:SAB4200236-200UL
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| | ANTI-LAMIN A/C Basic information |
| Product Name: | ANTI-LAMIN A/C | | Synonyms: | ANTI-LMN1;ANTI-LMNA;ANTI-LAMA;ANTI-LAMIN A/C;ANTI-LAMIN A/C(346);ANTI-LAMIN A/C(636);ANTI-LAMIN A/C(N-18);ANTI-LAMIN A (C-TERMINAL) | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![ANTI-LAMIN A/C Structure]() |
| | ANTI-LAMIN A/C Chemical Properties |
| storage temp. | −20°C | | form | buffered aqueous solution |
| | ANTI-LAMIN A/C Usage And Synthesis |
| Uses | Anti-Lamin A (C-terminal) antibody is suitable for use in western blot (0.1-0.2 μg/mL) using HeLa nuclear extract. This antibody can also be used in indirect immunofluorescence (1-2 μg/mL) using HeLa cells, rat NRK and mouse 3T3 cells. Additionally, anti-Lamin A (C-terminal) antibodies are suitable for use in immunoblotting (approx. 70 kDa). Cleaved fragments of lamin A may form additional bands at 45-50 kDa. | | Uses | Mouse monoclonal clone 4C11 anti-Lamin A/C antibody is used to tag lamins A and/or C for detection and quantitation by immunocytochemical and immunohistochemical (IHC) techniques such as immunoblotting, immunoprecipitation, and immunofluorescence. It is used as a probe to determine the presence and roles of lamins A and/or C in nuclear envelope structure and function. This antibody may be used in several immunochemical techniques including immunoblotting (~72/63 kDa), immunoprecipitation and immunofluorescence. | | General Description | Lamin is a structural protein of the nuclear lamina. Lamin A is a type A lamin encoded by the LMNA gene. Lamin A contains 664 amino acids and is expressed in most somatic cells. It contains α-helical rod domain to enable assembly into filaments, a nuclear localization sequence, and a carboxy-terminal CAAX box isoprenylation sequence for nuclear membrane targeting. | | Biochem/physiol Actions | Lamin A cut into a 47kDa fragment that facilitates chromatin condensation and nuclear degradation during cell death |
| | ANTI-LAMIN A/C Preparation Products And Raw materials |
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