FK-448 Free base
| 中文名称 | FK-448 Free base |
|---|---|
| 中文同义词 | 化合物 T11290 |
| 英文名称 | FK-448 Free base |
| 英文同义词 | FK-448 Free base;1-Naphthalenecarboxylic acid, 1,2,3,4-tetrahydro-, 4-[[4-(1-methylethyl)-1-piperazinyl]carbonyl]phenyl ester;FK 448 Free base,FK448 Free base |
| CAS号 | 85858-76-0 |
| 分子式 | C25H30N2O3 |
| 分子量 | 406.52 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 85858-76-0.mol |
| 结构式 |  |
FK-448 Free base 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | 溶于二甲基亚砜 |
IC50: 720 nM (Chymotrypsin)
FK-448 Free base is an effective and specific inhibitor of chymotrypsin, with an IC 50 of 720 nM. FK-448 Free base slightly inhibits esterolysis of Trypsin and Thrombin, with IC 50 s of 780 and 35 μM, respectively, but shows no effects on esterolysis of plasmin, plasma kallikrein or pancreas kallikrein, with IC 50 s of all >1 mM. FK-448 moderately inhibits hydrolytic activities of cathepsin G with an IC 50 of 15 μM.
FK-448 (20 mg/kg, i.p.) results in a decrease in the blood glucose level, and inhibits the degradation of insulin by pancreatic enzymes in rats. FK-448 (20 mg/kg, p.o.) also decreases the blood glucose level, and increases plasma IRI level in dogs.