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GRAMICIDIN

GRAMICIDIN Suppliers list
Company Name: Fuxin Pharmaceutical
Tel: +86-021-021-50872116 +8613122107989
Email: contact@fuxinpharm.com
Products Intro: Product Name:Gramicidin
CAS:1405-97-6
Purity:99% Package:1kg; 25kg; or larger package as required
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: +86-0371-55170693 +86-19937530512
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Products Intro: Product Name:Gramicidin
CAS:1405-97-6
Purity:99% Package:25KG;5KG;1KG
Company Name: career henan chemical co
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Email: sales@coreychem.com
Products Intro: Product Name:GRAMICIDIN
CAS:1405-97-6
Purity:98% Package:1KG;1USD
Company Name: Chongqing Chemdad Co., Ltd
Tel: +86-023-61398051 +8613650506873
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Products Intro: Product Name:GRAMICIDIN
CAS:1405-97-6
Purity:0.98 Package:1kg,2kg,5kg,10kg,25kg
Company Name: Shaanxi Dideu Medichem Co. Ltd
Tel: 18192627656
Email: 1012@dideu.com
Products Intro: Product Name:GRAMICIDIN
CAS:1405-97-6
Purity:99% Package:1KG;0.01USD|25KG;0.1USD|200KG;1USD

GRAMICIDIN manufacturers

  • Gramicidin
  • Gramicidin pictures
  • $200.70 / 1Kg/Bag
  • 2023-03-06
  • CAS:1405-97-6
  • Min. Order: 10g
  • Purity: 99%
  • Supply Ability: 10000kg
  • GRAMICIDIN USP/EP/BP
  • GRAMICIDIN USP/EP/BP pictures
  • $1.10 / 1g
  • 2021-07-17
  • CAS:1405-97-6
  • Min. Order: 1g
  • Purity: 99.9%
  • Supply Ability: 100 Tons Min
  • GRAMICIDIN
  • GRAMICIDIN  pictures
  • $0.01 / 1KG
  • 2020-05-12
  • CAS:1405-97-6
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 50 tons
GRAMICIDIN Basic information
Product Name:GRAMICIDIN
Synonyms:gramicidin from bacillus brevis*(gramicidin D);Gramicidin micronized USP23;GramicidinN.F.Xiv;gramicidin from bacillus aneurinolyticus (bacillus brevis);GRAMICIDIN,USP;GRAMACIDIN D;GRAMICIDIN;GRAMICIDIN D [DUBOS]
CAS:1405-97-6
MF:C99H140N20O17
MW:1882.2947
EINECS:215-790-4
Product Categories:A - KAntibiotics;Antibacterial;Antibiotics A to;Antibiotics G-MAntibiotics;Chemical Structure Class;Inhibits an EnzymeAntibiotics;Interferes with Cell Membrane Permeability (Ionophores)Antibiotics;Mechanism of Action;Peptides;Spectrum of Activity;PeptidesMulti-Drug Resistance;Substrates for Drug Efflux PumpsMore...Close...;Drug Efflux Pumps
Mol File:1405-97-6.mol
GRAMICIDIN Structure
GRAMICIDIN Chemical Properties
Melting point 229-230℃
storage temp. 2-8°C
solubility Practically insoluble in water, soluble in methanol, sparingly soluble in alcohol
color White to Off-White
Water Solubility Soluble in acetic acid and lower alcohols. Practically insoluble in water.
InChIKeyZWCXYZRRTRDGQE-SORVKSEFSA-N
CAS DataBase Reference1405-97-6
Safety Information
Hazard Codes Xn
Risk Statements 20/21-36/37/38
Safety Statements 26-36-24/25-22
WGK Germany 3
RTECS MD8225000
HS Code 2941906000
Toxicitymouse,LD50,intravenous,1500ug/kg (1.5mg/kg),Science. Vol. 103, Pg. 419, 1946.
MSDS Information
ProviderLanguage
SigmaAldrich English
GRAMICIDIN Usage And Synthesis
DescriptionGramicidin is a polypeptide antibiotic mixture of gramicidin A , gramicidin B, and gramicidin C originally isolated from B. brevis. It is also a component of the antibiotic tyrothricin . Gramicidin is active against the Gram-positive bacterium S. aureus but not Gram-negative E. coli. It also protects mice from Pneumococcus infection in vivo when administered at a dose of 0.002 mg/animal. Gramicidin inhibits growth of bacteria by forming pores and channels in the cell wall, which increases its permeability to monovalent cations. Formulations containing gramicidin have been used as topical agents in the treatment of bacterial skin infections.
Chemical PropertiesWhite, crystalline platelets. Soluble in lower alcohols, acetic acid, and pyridine; moderately soluble in dry acetone and dioxane; almost insoluble in water, ether, and hydrocarbons. Depresses surface tension, forms a fairly stable colloidal emulsion in distilled water.
UsesGramicidins are a family of linear pentadecapeptides isolated from Bacillus brevis by Dubos at the Rockefeller Institute in 1939. Gramicidin is a complex of six closely related analogues A1, A2, B1, B2, C1 and C2 where A1 and A2 are the dominant components. Gramidicins act by forming channels in cell membranes causing ion leakage, and is an essential bioprobe for understanding the nature of the cell membranes.
UsesMedicine (antibacterial).
UsesTargets primarily the cell membrane of Gram-positive bacteria and shows little effect against Gram-negative bacteria. Gramicidin is typically used as a topical antimicrobial agent because it also causes hemolysis of red blood cells.
DefinitionAn antibiotic produced by the metabolic processes of the bacteria Bacillus brevis. It is a polypeptide that is active against most Gram-positive pathogenic bacteria. It is one of the two antibiotic components of tyrothricin but has been isolated and used
Brand nameGramoderm (Schering).
Antimicrobial activityGramicidin is highly active against many Gram-positive bacteria. Neisseria spp. are relatively resistant. Gram-negative bacilli including Pseudomonas aeruginosa are susceptible although conflicting data exist about the degree of susceptibility. Gramicidin has a bactericidal activity against Mycoplasma spp. and several pathogenic fungi, including Candida albicans. Interestingly, it also appears to have antiviral activity against HIV and herpes simplex viruses (HSV-1, HSV-2).
General DescriptionGramicidin is obtained from tyrothricin, a mixture ofpolypeptides usually obtained by extraction of cultures of B.brevis. Tyrothricin was isolated in 1939 by Dubos in aplanned search to find an organism growing in soil that wouldhave antibiotic activity against human pathogens. With onlylimited use in therapy now, it is of historical interest as thefirst in the series of modern antibiotics. Tyrothricin is a whiteto slightly gray or brown-white powder, with little or no odoror taste. It is practically insoluble in water and is soluble in alcoholand dilute acids. Suspensions for clinical use can beprepared by adding an alcoholic solution to calculatedamounts of distilled water or isotonic saline solutions.
Gramicidin acts as an ionophore in bacterial cell membranesto cause the loss of potassium ion from the cell. Itis bactericidal.Tyrothricin and gramicidin are effective primarilyagainst Gram-positive organisms. Their use is restricted tolocal applications. Tyrothricin can cause lysis of erythrocytes,which makes it unsuitable for the treatment of systemicinfections. Its applications should avoid direct contactwith the bloodstream through open wounds or abrasions. Itis ordinarily safe to use tyrothricin in troches for throat infections,as it is not absorbed from the GI tract. Gramicidinis available in various topical preparations containing otherantibiotics, such as bacitracin and neomycin.
Pharmaceutical ApplicationsGramicidin as used in topical formulations is a mixture of several closely related compounds, of which about 80% is in the form of gramicidin A. It is part of the tyrothricin complex originally isolated from B. brevis.
It is active against most species of Gram-positive bacteria, including mycobacteria. Gram-negative bacilli are completely insensitive.
It is highly toxic to erythrocytes, liver and kidney, and is used only in topical formulations, usually as one of several components.
Biochem/physiol ActionsLinear polypeptide antibiotic mixture of gramicidin A, B, C, and D. Gramicidin A acts as neutral carrier and helps in the establishment of ion flux across the lipid bilayer.
Mechanism of actionThe mechanisms of gramicidin’s bactericidal activity have not been fully elucidated. Gramicidin is known to alter the function of the bacterial cytoplasmic membrane by forming channels that destroy the ion gradient and make it permeable for inorganic cations . It may also be a potent and specific inhibitor of the transcription reaction and inhibit the binding of DNA-dependent RNA polymerase (transcriptase) to DNA . Gramicidin appears to have antiviral activity against HIV, HSV-1, and HSV-2 viruses and is also used as a contraceptive due to its spermostatic properties.
Clinical UseThe use of gramicidin is restricted to topical applications on wounds or as ear and eye drops. Currently, much research is being invested to generate less toxic analogs that still exhibit the same wide range of bactericidal activity. To date, no new gramicidin-like polypeptides are available for clinical use. Gramicidin is used in some countries as a topical contraceptive, because it has spermostatic activity.
GRAMICIDIN Preparation Products And Raw materials
Raw materialsMonoethanolamine
Tag:GRAMICIDIN(1405-97-6) Related Product Information
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