1-PALMITYLTHIO-2-PALMITOYLAMIDO-1,2-DIDEOXY-SN-GLYCERO-3-PHOSPHOCHOLINE
| 中文名称 | 1-PALMITYLTHIO-2-PALMITOYLAMIDO-1,2-DIDEOXY-SN-GLYCERO-3-PHOSPHOCHOLINE |
|---|---|
| 中文同义词 | 化合物:Thioetheramide-PC CAS:116457-99-9;化合物：Thioetheramide-PC CAS:116457-99-9;硫醚酰胺PC |
| 英文名称 | 1-Palmitylthio-2-palmitoylamido-1,2-dideoxy-sn-glycero-3-phosphocholine |
| 英文同义词 | 1,2-DIDEOXY-1-(S-HEXADECYL)THIO-2-(N-HEXADECANOYL)AMINO-SN-GLYCERYL-3-PHOSPHORYLCHOLINE;1-PALMITYLTHIO-2-PALMITOYLAMIDO-1,2-DIDEOXY-SN-GLYCERO-3-PHOSPHORYLCHOLINE;1-PALMITYLTHIO-2-PALMITOYLAMINO-1,2-DIDEOXY-SN-GLYCERO-3-PHOSPHORYLCHOLINE;THIOETHERAMIDE PC;Thioetheramide phosphorylcholine;WLWWVTPUDQTUJU-KDXMTYKHSA-N;3,5-Dioxa-9-thia-4-phosphapentacosan-1-aminium, 4-hydroxy-N,N,N-trimethyl-7-[(1-oxohexadecyl)amino]-, inner salt, 4-oxide, (7S)-;1-Palmitylthio-2-palmitoylamido-1,2-dideoxy-sn-glycero-3-phosphocholine |
| CAS号 | 116457-99-9 |
| 分子式 | C45H93N2O4PS |
| 分子量 | 789.27 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 116457-99-9.mol |
| 结构式 |  |
1-PALMITYLTHIO-2-PALMITOYLAMIDO-1,2-DIDEOXY-SN-GLYCERO-3-PHOSPHOCHOLINE 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | 溶于DMSO；溶于二甲基甲酰胺 |
| 形态 | 白色固体。 |
Thioetheramide-PC (1-Palmitylthio-2-palmitoylamido-1,2-dideoxy-sn-glycero-3-phosphorylcholine) 是一种结构改良的磷脂，可作为分泌性磷脂酶 A2 (sPLA2) 的竞争性可逆抑制剂。Thioetheramide-PC (1-Palmitylthio-2-palmitoylamido-1,2-dideoxy-sn-glycero-3-phosphorylcholine) 的 IC50 值为 2 μM，底物浓度为 0.5 mM。除了与 sPLA2 的催化位点结合外，Thioetheramide-PC (1-Palmitylthio-2-palmitoylamido-1,2-dideoxy-sn-glycero-3-phosphorylcholine) 还与该酶的激活位点结合。Thioetheramide-PC (1-Palmitylthio-2-palmitoylamido-1,2-dideoxy-sn-glycero-3-phosphorylcholine) 与激活位点的结合比与催化位点的结合更紧密。这种双重相互作用的结果 是，在低浓度下，Thioetheramide-PC (1-Palmitylthio-2-palmitoylamido-1,2-dideoxy-sn-glycero-3-phosphorylcholine) 可能会激活磷脂酶活性，而不 是抑制它。