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Meclizine Dihydrochloride Monohydrate

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Products Intro: Product Name:Meclizine Hydrochloride API
CAS:31884-77-2
Purity:99% Package:25KG;5KG;1KG
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CAS:31884-77-2
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CAS:31884-77-2
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CAS:31884-77-2
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Products Intro: Product Name:Meclizine dihydrochloride
CAS:31884-77-2
Purity:0.99 Package:1kg,5kg,25kgs,200kgs;bulk

Meclizine Dihydrochloride Monohydrate manufacturers

Meclizine Dihydrochloride Monohydrate Basic information
Product Name:Meclizine Dihydrochloride Monohydrate
Synonyms:Meclizine dihydrochloride monohydrate;1-[(4-Chlorophenyl)phenylMethyl]-4-[(3-Methylphenyl)Methyl]piperazine DiHydrochloride Hydrate;Meclizine Related CoMpound B;MECLIZINE HYDROCHLORIDE (500 MG);Meclizine hydrochloride;Antivert;Permesin;MECLIZINE HYDROCHLORIDE MONOHYDRATE
CAS:31884-77-2
MF:C25H27ClN2.2ClH.H2O
MW:481.892
EINECS:688-525-7
Product Categories:Intermediates & Fine Chemicals;Pharmaceuticals;Aromatics;Heterocycles
Mol File:31884-77-2.mol
Meclizine Dihydrochloride Monohydrate Structure
Meclizine Dihydrochloride Monohydrate Chemical Properties
Melting point 210-213°C
storage temp. -20°C Freezer
solubility Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form Solid
color White
Water Solubility Insoluble in water.
CAS DataBase Reference31884-77-2
Safety Information
TSCA Yes
HS Code 2933599550
MSDS Information
Meclizine Dihydrochloride Monohydrate Usage And Synthesis
Chemical PropertiesWhite Solid
OriginatorAntivert,Roerig,US,1957
UsesAntiemetic and H1-histamine receptor antagonistMeclizine dihydrochloride monohydrate acts as an antiemetic. It is also used for the prevention and treatment of nausea during pregnancy. In addition to this, it is used in radiation sickness, vomiting or dizziness associated with motion sickness. Product purchased here is only for use in Research and Development.
UsesMeclizine Dihydrochloride Monohydrate is used for the prevention and treatment of nausea, vomiting, or dizziness associated with motion sickness.
DefinitionChEBI: Meclizine hydrochloride is a diarylmethane.
Manufacturing Process32.3 g of 1-p-chlorobenzhydryl-4-benzyl-piperazine, dissolved in 300 cm3 of alcohol are heated in an autoclave vessel, in the presence of Raney nickel, under a pressure of 100 kg H2, at about 150°C for 6 hours. The catalyst is filtered, the solvent is evaporated and the residue is fractionated under a high vacuum. p-Chlorobenzylhydryl-piperazine (BP 180° to 185°C/1 mm Hg) is isolated with a yield of 75%. Then finely ground NaNH2 is added. The mixture is heated under reflux for 1 hour, the mass is cooled and a molar equivalent of m-methyl benzyl chloride is added.
The solvent is evaporated and the residue is dissolved in chloroform. This solution is washed with a saturated solution of K2CO3 and dried on K2CO3. The solvent is evaporated and the residue is distilled under high vacuum. The product of the condensation distills near 230°C at 2 mm Hg pressure and the corresponding dihydrochloride melts at 217° to 224°C.
Brand nameAntivert (Pfizer).
Therapeutic FunctionAntinauseant
General DescriptionMeclizine hydrochloride,1-(p-chloro-α-phenylbenzyl)-4-(m-methylbenzyl)piperazinedihydrochloride monohydrate (Bonine, Antivert), is atasteless, white or slightly yellowish crystalline powder that is practically insoluble in water (1:1,000). It differs fromchlorcyclizine in having an N-m-methylbenzyl group inplace of the N-methyl group. Although it is a moderately potentantihistaminic, meclizine is used primarily as an antinauseantin the prevention and treatment of motion sicknessand in the treatment of nausea and vomiting associated withvertigo.
Meclizine Dihydrochloride Monohydrate Preparation Products And Raw materials
Raw materialsSodium amide-->Hydrogen-->3-Methylbenzyl chloride
Tag:Meclizine Dihydrochloride Monohydrate(31884-77-2) Related Product Information
Dimenhydrinate Betahistine dihydrochloride Meclozine CHLORCYCLIZINE CHLORCYCLIZINE HYDROCHLORIDE Meclizine Dihydrochloride Monohydrate Chlorcyclizine dihydrochloride 1-[(4-CHLOROPHENYL)PHENYLMETHYL]-PIPERAZINE DIHYDROCHLORIDE 1-(4-CHLOROBENZYL)PIPERAZINE (4-CHLOROPHENYL)PHENYLMETHYLAMINE HYDROCHLORIDE Meclizine dihydrochloride 1-(4-Chlorobenzhydryl)piperazine 1-(3-METHYLBENZYL)PIPERAZINE