Tyrphostin AG1433
| 中文名称 | Tyrphostin AG1433 |
|---|---|
| 中文同义词 | 化合物 T13238;4-(6,7-二甲基喹喔啉-2-基)苯-1,2-二醇;化合物TYRPHOSTIN AG1433;酪磷素AG1433 |
| 英文名称 | Tyrphostin AG1433 |
| 英文同义词 | 1,2-Benzenediol, 4-(6,7-dimethyl-2-quinoxalinyl)-;cytotoxicity,PDGFRβ,Tyrphostin AG 1433,AG-1433,Tyrphostin AG1433,VEGFR,AG 1433,kinases,Vascular endothelial growth factor receptor,SU 1433,Tyrphostin AG-1433,Platelet-derived growth factor receptor,angiogenesis,tyrosine,inhibit,VEGFR-2,Inhibitor,ATM,PDGFR,SU-1433 |
| CAS号 | 168835-90-3 |
| 分子式 | C16H14N2O2 |
| 分子量 | 266.29 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 168835-90-3.mol |
| 结构式 |  |
Tyrphostin AG1433 性质
| 熔点 | 280-282 °C |
|---|---|
| 沸点 | 490.9±45.0 °C(Predicted) |
| 密度 | 1.300±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 二甲基亚砜：62.5 mg/mL（234.71 mM） |
| 酸度系数(pKa) | 8.32±0.20(Predicted) |
Tyrphostin AG1433 (SU1433) 是酪氨酸激酶抑制剂。Tyrphostin AG1433 还是一种选择性的 PDGFRβ 和 VEGFR-2 (Flk-1/KDR) 抑制剂，IC50 分别为 5.0 μM 和 9.3 μM。Tyrphostin AG1433 可防止血管形成。
|
Flk-1 9.3 μM (IC 50 ) |
PDGFRβ 5 μM (IC 50 ) |
Tyrphostin AG1433 (0.1-100 μM; 72 hours; GB8B cells) treatment induces moderate cytotoxicity in glioblastoma cells.
Cell Viability Assay
| Cell Line: | GB8B cells |
| Concentration: | 0.1 μM, 1 μM, 5 μM, 10 μM, 20 μM, 30 μM, 50 μM, 60 μM, 100 μM |
| Incubation Time: | 72 hours |
| Result: | Induced significant cell death in GB8B cells in a concentration-dependent manner. |
Chorion allantoic membrane (CAM) assays are used to determine the effects of the Flk-i inhibitors on angiogenesis. Tyrphostin AG1433 (SU1433) is prepared in methylcellulose pellets and applies to the CAMs of 4-6-day-old chicken embryos. Tyrphostin AG1433 prevents the formation of new yessels under the pellets.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/16 | S0763 | Tyrphostin AG1433 Tyrphostin AG1433 | 168835-90-3 | 5mg | 2678.13元 |
| 2024/01/16 | S0763 | Tyrphostin AG1433 Tyrphostin AG1433 | 168835-90-3 | 25mg | 8099.91元 |