化合物T7747
| 中文名称 | 化合物T7747 |
|---|---|
| 中文同义词 | 化合物T7747;化合物 DATELLIPTIUM CHLORIDE HYDROCHLORIDE |
| 英文名称 | Datelliptium chloride hydrochloride |
| 英文同义词 | Datelliptium chloride hydrochloride;antitumoral,Datelliptium chloride hydrochloride,DNA/RNA Synthesis,activity,Inhibitor,Ellipticine,hepatotoxicity,inhibit,Datelliptium chloride,antineoplastic |
| CAS号 | 157000-76-5 |
| 分子式 | C23H28ClN3O |
| 分子量 | 397.95 |
| EINECS号 | |
| 相关类别 | 标准品 |
| Mol文件 | 157000-76-5.mol |
| 结构式 |  |
化合物T7747 性质
| 溶解度 | DMSO: Sparingly soluble: 1-10 mg/ml Ethanol: Soluble: = 10 mg/mlPBS (pH 7.2): Sparingly soluble: 1-10 mg/ml |
|---|
Datelliptium chloride hydrochloride 是一种由 Ellipticine (HY-15753) 衍生的 DNA 嵌合剂。Datelliptium chloride hydrochloride 在体内对多种小鼠实体瘤有效。
Datelliptium chloride hydrochloride shows cytotoxic effects after 2 hours of treatment in suspension and primary cultures of rat hepatocytes.
Datelliptium chloride hydrochloride has broad antitumor activity against solid tumors of mice in vivo.
Datelliptium chloride hydrochloride (170 mg/kg; i.v; for 12 days) exhibits a high degree of antitumor activity at early staged disease.
Datelliptium chloride hydrochloride is selectively cytotoxic for solid tumors over leukemia L1210.
| Animal Model: | Mice, colon adenocarcinoma early staged disease model |
| Dosage: | 170 mg/kg |
| Administration: | Intravenous injection, for 12 days |
| Result: | Highly active against colon adenocarcinoma. |