EIPA Suppliers list
Company Name: BOC Sciences
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Products Intro: Product Name:EIPA
Purity:98% by HPLC Package:50 mg Remarks:EIPA is a TRPP3 channel inhibitor (IC50 = 10.5 μM). EIPA also acts as an Na+/H+ exchange inhibitor that suppresses the Na+/H+ exchanger (NHE).https://www.bocsci.com/eipa-cas-1154-25-2-item-47130.html
Company Name: Career Henan Chemica Co
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Products Intro: Product Name:EIPA
Purity:0.99, AD68 Package:1g;11USD
Company Name: J & K SCIENTIFIC LTD.  
Tel: 010-82848833 400-666-7788
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Products Intro: Product Name:5-(N-Ethyl-N-isopropyl) AMiloride
Company Name: 3B Pharmachem (Wuhan) International Co.,Ltd.  
Tel: 821-50328103-801 18930552037
Email: 3bsc@sina.com
Products Intro: Product Name:EIPA
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
Company Name: Chemsky(shanghai)International Co.,Ltd.  
Tel: 021-50135380
Email: shchemsky@sina.com
Products Intro: Product Name:5-(N-Ethyl-N-isopropyl) AMiloride
EIPA Basic information
Product Name:EIPA
Synonyms:AMILORIDE, 5-(N-ETHYL-N-ISOPROPYL)-;5-(N-ETHYL-N-ISOPROPYL)AMILORIDE;3-AMINO-N-(AMINOIMINOMETHYL)-6-CHLORO-5-[ETHYL(2-PROPYL)AMINO]-PYRAZINE-2-CARBOXAMIDE;EIPA;3-Amino-N-(aminoiminomethyl)-6-chloro-5-[ethyl(1-methylethyl)amino]-2-pyrazinecarboxamide;L 593754;MH 12-43;3-Amino-5-(N-ethyl-N-isopropylamino)-6-chloro-N-(aminoiminomethyl)-2-pyrazinecarboxamide
Product Categories:All Inhibitors;Bases & Related Reagents;Inhibitors;Intermediates & Fine Chemicals;Nucleotides;Pharmaceuticals
Mol File:1154-25-2.mol
EIPA Structure
EIPA Chemical Properties
Melting point 202-205 °C(lit.)
density 1.49±0.1 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,2-8°C
solubility Acetonitrile (Slightly, Heated), DMSO (Slightly), Methanol (Slightly)
form Off-white to yellow solid.
color Pale Yellow to Green
Stability:Unstable in methanol
CAS DataBase Reference1154-25-2
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-37/39
WGK Germany 3
HazardClass 6.1(b)
PackingGroup III
MSDS Information
SigmaAldrich English
EIPA Usage And Synthesis
DescriptionSodium-hydrogen exchangers (NHE) are involved in maintaining sodium and pH balance in a variety of tissues. They are also known as sodium-hydrogen antiporters and solute carrier family 9 members. 5-(N-ethyl-N-isopropyl)-Amiloride (EIPA) is a potent inhibitor of several NHE isoforms, inhibiting NHE1, NHE2, NHE3, and NHE5 with Ki values of 0.02, 0.5, 2.4, and 0.42 μM, respectively. It less effectively inhibits NHE4 (IC50 ≥10 μM). EIPA is commonly used at a concentration of 5-10 μM to inhibit cellular HNE activity.
Chemical PropertiesYellow Solid
Uses5-(N-Ethyl-N-isopropyl)amiloride has been used:
  • as a supplement in endothelial cell growth medium to incubate human lung microvascular endothelial cell
  • in Pluronic F-127 stock solution for Drosophila larval live-imaging
  • in choline chloride solution as an experimental perfusate, to study the effect of Na+/H+ inhibition on jejunal loop perfusion in vivo

UsesSelective Na+/H+ antiporter inhibitor. Selectively enhances the excretion of sodium ions without causing an increase in excretion of potassium ions.
UsesSelective Na+/H+ antiporter inhibitor. Selectively enhances the excretion of sodium ions without causing an increase in excretion of potassium ions
DefinitionChEBI: Ethylisopropylamiloride is a member of the class of pyrazines that is amiloride in which the amino substitutent of the pyrazine ring that is adjacent to the chloro substituent has been substituted by an ethyl group and by an isopropyl group. It has a role as an anti-arrhythmia drug, a neuroprotective agent and a sodium channel blocker. It is a member of guanidines, an aromatic amine, an organochlorine compound, a tertiary amino compound, a member of pyrazines and a monocarboxylic acid amide. It is functionally related to an amiloride.
Biochem/physiol ActionsSelective blocker of Na+/H+ antiport
EIPA Preparation Products And Raw materials
Tag:EIPA(1154-25-2) Related Product Information
N-ethyl-pyrrolidone 2-pyrazinoylguanidine AMILORIDE 2-Chloro-6-methylpyrazine EIPA (PYRAZIN-2-YL)METHANAMINEHYDROCHLORIDE 2-Amino-5-chloropyrazine Pyrazinecarboxaldehyde, 5-(dimethylamino)- (9CI) 3-AMINO-N-METHYLPYRAZINE-2-CARBOXAMIDE 6-CHLORO-3,5-DIAMINO-2-PYRAZINECARBOXAMIDE 2-amino-3-chloro-5-methyl-pyrazine 5-(N,N-HEXAMETHYLENE)-AMILORIDE 3-AMINO-6-CHLOROPYRAZINE-2-CARBALDEHYDE 2,6-Pyrazinediamine(9CI) 5-(N-Ethyl-N-isopropyl)amiloridehydrochloride 6-CHLORO-2-PYRAZINECARBOXAMIDE 5-AMINOPYRAZINE-2-CARBOXAMIDE 2-AMINO-3-CHLOROPYRAZINE