抗菌肽Indolicidin
中文名称 | 抗菌肽Indolicidin |
---|---|
中文同义词 | INDOLICIDIN肽;IR-13-NH2;抗菌肽INDOLICIDIN |
英文名称 | INDOLICIDIN |
英文同义词 | INDOLICIDIN;L-ArgininaMide,L-isoleucyl-L-leucyl-L-prolyl-L-tryptophyl-L-lysyl-L-tryptophyl-L-prolyl-L-tryptophyl-L-tryptophyl-L-prolyl-L-tryptophyl-L-arginyl-;42: PN: US7381704 SEQID: 42 claimed sequence;IndolicidinIndolicid;H-ILE-LEU-PRO-TRP-LYS-TRP-PRO-TRP-TRP-PRO-TRP-ARG-ARG-NH2;ILPWKWPWWPWRR-NH2;ILE-LEU-PRO-TRP-LYS-TRP-PRO-TRP-TRP-PRO-TRP-ARG-ARG-NH2;Indolicidin, ≥97% (HPLC) |
CAS号 | 140896-21-5 |
分子式 | C100H132N26O13 |
分子量 | 1906.28 |
EINECS号 | |
相关类别 | 细胞生物学;细胞信号和神经生物学;多肽;原料药;多肽-客户肽;目录多肽;Peptide |
Mol文件 | 140896-21-5.mol |
结构式 |
抗菌肽Indolicidin 性质
密度 | 1.45±0.1 g/cm3(Predicted) |
---|---|
RTECS号 | NM1890250 |
储存条件 | −20°C |
溶解度 | 可微溶于水 |
形态 | 粉末 |
酸度系数(pKa) | 13.29±0.46(Predicted) |
水溶解性 | Soluble in water (1 mg/ml). |
序列 | H--Ile-Leu-Pro-Trp-Lys-Trp-Pro-Trp-Trp-Pro-Trp-Arg-Arg-NH2 |
Indolicidin is comprised of 13 amino acids, 5 of which are tryptophan residues, and the carboxylterminal arginine is carboxamidated. Indolicidin has the highest tryptophan content of any known protein. The multiple tryptophan residues may play an important role in the function of this unique antibiotic peptide. Indolicidin is a tridecapeptide amide which possesses in vitro bactericidal activities comparable with the most active of the defensin or bactenecin peptides. Indolicidin binds purified surface lipopolysaccharide with high affinity and permeabilized the outer membrane of Escherichia coli to the small hydrophobic molecule 1-N-phenylnapthylamine (Mr 200), results consistent with indolicidin crossing the outer membrane via the self-promoted uptake pathway. The methyl esterification of indolicidin's carboxyl terminus increases its activity for Gram-negative and Gram-positive bacteria. In Gram-negative bacteria this is associated with an increased binding to lipopolysaccharide and increased permeabilization of the outer membrane. The cytoplasmic membrane is the site of action of indolicidin as assayed in Escherichia coli by the unmasking of cytoplasmic beta-galactosidase due to membrane permeabilization.
纯度(HPLC) ≥98.0%
醋酸根含量≤12.0%
水分含量≤8.0%
肽含量≥80.0%
内毒素≤50EU/mg
氨基酸组成分析≤±10%
安全信息
WGK Germany | 3 |
---|
提供商 | 语言 |
---|---|
英文
|
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024/01/25 | HY-P0261 | ILE-LEU-PRO-TRP-LYS-TRP-PRO-TRP-TRP-PRO-TRP-ARG-ARG-NH2 Indolicidin | 140896-21-5 | 500μg | 1600元 |
2024/01/25 | HY-P0261 | ILE-LEU-PRO-TRP-LYS-TRP-PRO-TRP-TRP-PRO-TRP-ARG-ARG-NH2 Indolicidin | 140896-21-5 | 1mg | 2600元 |