氧托溴铵
| 中文名称 | 氧托溴铵 |
|---|---|
| 中文同义词 | 氧托溴铵;氧托溴铵 EP标准品;溴化氧托溴铵;化合物 T16417 |
| 英文名称 | OXITROPIUM BROMIDE |
| 英文同义词 | (-)-n-ethyl-norhyoscine-methobromide;3-oxa-9-azoniatricyclo(3.3.1.0(sup2,4))nonane,9-ethyl-7-(3-hydroxy-1-oxo-2-ph;ba253br;ba-253-br-l;bromurodeoxitropio;Oxivent;Scopolamine ethobromide;Tersigan |
| CAS号 | 30286-75-0 |
| 分子式 | C19H26BrNO4 |
| 分子量 | 412.32 |
| EINECS号 | 250-113-6 |
| 相关类别 | |
| Mol文件 | 30286-75-0.mol |
| 结构式 |  |
氧托溴铵 性质
| 熔点 | 203-204° (dec) |
|---|---|
| 比旋光度 | D21 -25° (c = 2.0 in water) |
| 储存条件 | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| 溶解度 | 极易溶于水，易溶于甲醇，微溶于乙醇（96%），几乎不溶于二氯甲烷。 |
| 颜色 | 灰白色至浅黄色 |
| 稳定性 | 吸湿性 |
mAChR
Oxitropium bromide is a muscarinic antagonist which blocks musucarinic acetylcholine receptors (mAChR). Incubation with oxitropium bromide of untreated diaphragm muscle and diaphragm muscle injected with endotoxin does not increase the force-frequency curves dose-dependently in vitro ; however, it causes both types of muscle to be fatigue resistant.
Oxitropium bromide inhalation shifts force-frequency curves upward at 2 h after inhalation and inhibits the decrease of force-frequency curves due to endotoxin injection in vivo . Oxitropium bromide strongly and persistently inhibits the acetylcholine (ACh)-induced resistance. The increase in resistance induced by histamine, serotonin, leukotriene D4 or antigen is prevented by oxitropium bromide oxitropium bromide. Inhalation of the anticholinergic agent oxitropium bromide at doses of 1.5 μg and higher greatly attenuates the decrease in mucus score produced by intravenous histamine but not by inhaled histamine.
安全信息
| 毒性 | LD50 orl-rat: 2250 mg/kg DRFUD44,117,79 |
|---|