奥西那林
| 中文名称 | 奥西那林 |
|---|---|
| 中文同义词 | 奥西那林;5-(1-羟基-2-异丙基氨基乙基)苯-1,3-二酚;间羟异丙基肾上腺素;化合物 T16043;肾上腺素杂质43盐酸盐 |
| 英文名称 | Orciprenaline |
| 英文同义词 | 5-[1-hydroxy-2-(1-methylethylamino)ethyl]benzene-1,3-diol;5-(1-hydroxy-2-propan-2-ylamino-ethyl)benzene-1,3-diol;orciprenaline;1-(3,5-dihydroxyphenyl)-2-isopropylaminoethanol;1,3-Benzenediol, 5-1-hydroxy-2-(1-methylethyl)aminoethyl-;1,3-Benzenediol, 5-[1-hydroxy-2-[(1-methylethyl)amino]ethyl]- (9CI);3,5-Dihydroxy-a-[(isopropylamino)methyl]benzyl alcohol;Benzyl alcohol, 3,5-dihydroxy-a-[(isopropylamino)methyl]- (6CI, 8CI) |
| CAS号 | 586-06-1 |
| 分子式 | C11H17NO3 |
| 分子量 | 211.26 |
| EINECS号 | 2095691 |
| 相关类别 | 瘦肉精类;平喘药物;Orciprenaline |
| Mol文件 | 586-06-1.mol |
| 结构式 |  |
奥西那林 性质
| 熔点 | 100° |
|---|---|
| 沸点 | 350.94°C (rough estimate) |
| 密度 | 1.1240 (rough estimate) |
| 折射率 | 1.5718 (estimate) |
| 酸度系数(pKa) | 9.11±0.10(Predicted) |
| CAS 数据库 | 586-06-1(CAS DataBase Reference) |
IC50: 68 nM (β2-adrenergic receptor)
Metaproterenol (10 μM; 74 hours; THP-1 cells and bone marrow macrophages) treatment enhances β-arrestin2 and its interaction with IκBα in high glucose-induced THP-1 cells and bone marrow macrophages.
Metaproterenol (10 μM; 74 hours; THP-1 cells and bone marrow macrophages) treatment leads to downregulation of NF-κB in high glucose-induced THP-1 cells and bone marrow macrophages.
Western Blot Analysis
| Cell Line: | THP-1 cells and bone marrow macrophages |
| Concentration: | 10 μM |
| Incubation Time: | 74 hours |
| Result: | Enhanced β-arrestin2 and its interaction with IκBα. |
RT-PCR
| Cell Line: | THP-1 cells and bone marrow macrophages |
| Concentration: | 10 μM |
| Incubation Time: | 74 hours |
| Result: | Led to downregulation of NF-κB. |
Treatment of Zucker diabetic fatty rats with Metaproterenol for 12 weeks attenuates monocyte activation as well as pro-inflammatory and pro-fibrotic responses in the kidneys and heart. Thus, Metaproterenol might has protective effects against diabetic renal and cardiovascular complications.