氯丁扎利
| 中文名称 | 氯丁扎利 |
|---|---|
| 中文同义词 | 氯丁扎利;化合物 T10839 |
| 英文名称 | clobuzarit |
| 英文同义词 | 2-[(4'-Chloro[1,1'-biphenyl]-4-yl)methoxy]-2-methylpropanoic acid;2-[(4'-Chloro-4-biphenylyl)methoxy]-2-methylpropionic acid;2-[[4'-Chloro(1,1'-biphenyl)-4-yl]methoxy]-2-methylpropionic acid;Clozic;ICI-55897;clobuzarit;Propanoic acid, 2-[(4'-chloro[1,1'-biphenyl]-4-yl)methoxy]-2-methyl- |
| CAS号 | 22494-47-9 |
| 分子式 | C17H17ClO3 |
| 分子量 | 304.771 |
| EINECS号 | 2450354 |
| 相关类别 | |
| Mol文件 | 22494-47-9.mol |
| 结构式 |  |
氯丁扎利 性质
| 熔点 | 154-155° |
|---|---|
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
Clozic 是一种潜在的抗关节炎药物。
Clozic is a potential anti-arthritic agent. Concentrations of Clozic greater than 50 μM cause a dose-dependent decrease in the amount of matrix protein synthesized by RHMC cell cultures. Inhibition of RHMC cell culture growth by Clozic occurs in a dose-dependent manner. The anti-proliferative effect of Clozic on RHMC cell growth is reversible. Lactate dehydrogenase (LDH) levels in media taken from RHMC cell cultures exposed to 500 μM Clozic for 3 days do not significantly differ from LDH levels in control cell culture media.