| Company Name: |
J & K SCIENTIFIC LTD.
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010-82848833 400-666-7788 |
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jkinfo@jkchemical.com |
| Products Intro: |
Product Name:Etidocaine Hydrochloride
CAS:36637-19-1
Package:100Mg,1g
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| Company Name: |
Chemsky (shanghai) International Co.,Ltd
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| Tel: |
021-50135380 |
| Email: |
shchemsky@sina.com |
| Products Intro: |
Product Name:Etidocaine Hydrochloride;N-(2,6-diMethylphenyl)-2-(ethylpropylaMino)butanaMide Hydrochloride; (±)-N-(2,6-diMethylphenyl)-2-(ethylpropylaMino)butanaMide Monohydrochloride; Duranest; Duranest Hydrochloride; W 19053
CAS:36637-19-1
Purity:98+% Package:1Mg;5Mg;10Mg;50Mg;100Mg;500Mg
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| | (±)-N-(2,6-dimethylphenyl)-2-(ethylpropylamino)butyramide monohydrochloride Basic information |
| Product Name: | (±)-N-(2,6-dimethylphenyl)-2-(ethylpropylamino)butyramide monohydrochloride | | Synonyms: | (±)-N-(2,6-diMethylphenyl)-2-(ethylpropylaMino)butanaMide Monohydrochloride;(±)-N-(2,6-dimethylphenyl)-2-(ethylpropylamino)butyramide monohydrochloride;Etidocaine Hydrochloride;Duranest Hydrochloride;N-(2,6-diMethylphenyl)-2-(ethylpropylaMino)butanaMide Hydrochloride;ButanaMide, N-(2,6-diMethylphenyl)-2-(ethylpropylaMino)-, Monohydrochloride;Etidocaine hydrochlorideQ: What is
Etidocaine hydrochloride Q: What is the CAS Number of
Etidocaine hydrochloride Q: What is the storage condition of
Etidocaine hydrochloride Q: What are the applications of
Etidocaine hydrochloride;inhibit,Etidocaine Hydrochloride,Etidocaine,EDC,Inhibitor,anesthetics | | CAS: | 36637-19-1 | | MF: | C17H29ClN2O | | MW: | 312.87796 | | EINECS: | 2531443 | | Product Categories: | Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals | | Mol File: | 36637-19-1.mol |  |
| | (±)-N-(2,6-dimethylphenyl)-2-(ethylpropylamino)butyramide monohydrochloride Chemical Properties |
| Melting point | 203-203.5° | | storage temp. | Hygroscopic, Refrigerator, under inert atmosphere | | solubility | DMSO, Methanol | | form | Solid | | color | White to Off-White | | Stability: | Hygroscopic |
| Toxicity | LD50 in female mice (mg/kg): 6.7 i.v.; 99 s.c. (Adams, 1972) |
| | (±)-N-(2,6-dimethylphenyl)-2-(ethylpropylamino)butyramide monohydrochloride Usage And Synthesis |
| Originator | Duranest,Astra,US,1976 | | Uses | Etidocaine Hydrochloride is a local anesthetic amide used during surgical procedures and during labor in pregnancies. | | Definition | ChEBI: Etidocaine hydrochloride is an amino acid amide. | | Manufacturing Process | α-(n-Propylamino)-n-butyro-2,6-xylidide(0.243 mol) and freshly distilled
diethyl sulfate (1.6 mols were mixed in a flask equipped with reflux condenser,
drying tube and stirrer. The mixture was stirred for 5 hours at 90°C. After
cooling, water (110 ml) was added with stirring for 15 minutes followed by 4M
HCl (110 ml). The solution was washed with ether (3 X 100 ml) and made
alkaline with 7M NaOH to pH 10-11. The freed base was taken up in ether (3
X 100 ml); the extracts were dried over sodium sulfate, filtered and
evaporated. The residue was dissolved in absolute ether (200 ml) and the
hydrochloride prepared by addition of ethereal hydrogen chloride. The
precipitate was filtered, washed with ether, and recrystallized twice from
absolute ethanol/ether and from isopropanol/isopropylether; MP 203°C to
203.5°C; yield: 0.126 mol (52%).
The starting material is prepared by reacting 2-bromobutyric acid with sulfonyl
chloride to give the acid chloride. It is then reacted with 2,6-xylidine, then
with potassium iodide followed by n-propylamine. | | Therapeutic Function | Local anesthetic | | Biological Functions | Etidocaine hydrochloride (Duranest), although
chemically similar to lidocaine, has a more prolonged action. It is used for regional blocks, including epidural
anesthesia. It exhibits a preference for motor rather
than sensory block; therefore, its use in obstetrics is limited,
although fetal drug concentrations remain low. It
can be used with or without epinephrine. |
| | (±)-N-(2,6-dimethylphenyl)-2-(ethylpropylamino)butyramide monohydrochloride Preparation Products And Raw materials |
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