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1-Piperazineacetamide, 4-methyl-N-[4-methyl-5-[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]-2-thiazolyl]-

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1-Piperazineacetamide, 4-methyl-N-[4-methyl-5-[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]-2-thiazolyl]- Suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: CAS:2416844-79-4
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G
Company Name: TargetMol Chemicals Inc.
Tel: +17819995354
Email: marketing@targetmol.com
Products Intro: Product Name:IHMT-TRK-284
CAS:2416844-79-4
Package:100mg;3520USD|25mg;2140USD|50mg;2785USD
Company Name: Shanghai Chaolan Chemical Technology Center  
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Products Intro: Product Name:1-Piperazineacetamide, 4-methyl-N-[4-methyl-5-[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]-2-thiazolyl]-
CAS:2416844-79-4
Purity:98 Package:1G,5G,10G,50G,100G,500G
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Products Intro: Product Name:IHMT-TRK-284
CAS:2416844-79-4
Package:100mg/RMB 24625;25mg/RMB 14900;50mg/RMB 19420

1-Piperazineacetamide, 4-methyl-N-[4-methyl-5-[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]-2-thiazolyl]- manufacturers

  • IHMT-TRK-284
  • IHMT-TRK-284 pictures
  • $3520.00 / 100mg
  • 2025-10-27
  • CAS:2416844-79-4
  • Min. Order:
  • Purity:
  • Supply Ability: 10g
1-Piperazineacetamide, 4-methyl-N-[4-methyl-5-[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]-2-thiazolyl]- Basic information
Product Name:1-Piperazineacetamide, 4-methyl-N-[4-methyl-5-[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]-2-thiazolyl]-
Synonyms:1-Piperazineacetamide, 4-methyl-N-[4-methyl-5-[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]-2-thiazolyl]-;IHMT-TRK-284
CAS:2416844-79-4
MF:C25H27N7OS
MW:473.59
EINECS:
Product Categories:
Mol File:2416844-79-4.mol
1-Piperazineacetamide, 4-methyl-N-[4-methyl-5-[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]-2-thiazolyl]- Structure
1-Piperazineacetamide, 4-methyl-N-[4-methyl-5-[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]-2-thiazolyl]- Chemical Properties
density 1.339±0.06 g/cm3(Predicted)
pka9.06±0.50(Predicted)
Safety Information
MSDS Information
1-Piperazineacetamide, 4-methyl-N-[4-methyl-5-[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]-2-thiazolyl]- Usage And Synthesis
UsesIHMT-TRK-284 (Compound 34) is a potent, orally active type II TRK kinase inhibitor with IC50 values of 10.5, 0.7, and 2.6 nM to TRKA, B, and C respectively. IHMT-TRK-284 displays great selectivity profile in the kinome and good in vivo antitumor efficacies[1].
IC 50TrkB: 0.7 nM (IC50); TrkC: 2.6 nM (IC50); TrkA: 10.5 nM (IC50); CSF1R: 1.2 nM (IC50); PDGFRα: 24.2 nM (IC50); PDGFRβ: 95.7 nM (IC50); Abl1: 83.6 nM (IC50); KIT: 2167 nM (IC50)
References[1] Beilei Wang, et al. Discovery of (E)-N-(4-methyl-5-(3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thiazol-2-yl)-2-(4-methylpiperazin-1-yl)acetamide (IHMT-TRK-284) as a novel orally available type II TRK kinase inhibitor capable of overcoming multiple resistan DOI:10.1016/j.ejmech.2020.112744
1-Piperazineacetamide, 4-methyl-N-[4-methyl-5-[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]-2-thiazolyl]- Preparation Products And Raw materials
Tag:1-Piperazineacetamide, 4-methyl-N-[4-methyl-5-[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]-2-thiazolyl]-(2416844-79-4) Related Product Information
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