N-羟基胞苷
中文名称 | N-羟基胞苷 |
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中文同义词 | 1-((2R,3R,4S,5R)-3,4-二羟基-5-(羟甲基)四氢呋喃-2-基)-4-(羟基亚氨基)-3,4-二氢嘧啶-2(1H)-酮;N-羟基胞苷(NHC);莫那比拉韦杂质1;莫匹拉韦中EIDD-1931;莫匹拉韦中间体EIDD-1931;EIDD-1931 N-羟基胞苷;莫努匹韦杂质 1;莫努匹韦杂质 |
英文名称 | N(4)-hydroxycytidine |
英文同义词 | N(4)-hydroxycytidine;1-[(2R)-3α,4α-Dihydroxy-5β-(hydroxymethyl)oxolane-2β-yl]-4-(hydroxyamino)pyrimidine-2(1H)-one;3,4-Dihydro-1-β-D-ribofuranosyl-4-(hydroxyimino)pyrimidin-2(1H)-one;β-D-N4-Hydroxycytidine;Beta-d-N4-hydroxycytidine;Beta-d-N4-hydroxycytidine (NHC);Uridine, 4-oxime;EIDD2801 ,β-D-N4-hydroxycytidine |
CAS号 | 3258-02-4 |
分子式 | C9H13N3O6 |
分子量 | 259.22 |
EINECS号 | |
相关类别 | 芳香族;抑制剂;医药原料;化合物产品;化工原料;原料药及中间体类;杂质对照品;对照品 |
Mol文件 | 3258-02-4.mol |
结构式 |
N-羟基胞苷 性质
熔点 | 169-172 °C(Solv: methanol (67-56-1)) |
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密度 | 1.93±0.1 g/cm3(Predicted) |
储存条件 | Inert atmosphere,Store in freezer, under -20°C |
溶解度 | 可溶于DMSO(高达25mg/ml)或水(加热时高达15mg/ml)。 |
形态 | 固体 |
酸度系数(pKa) | 8.19±0.20(Predicted) |
颜色 | 白色 |
稳定性 | DMSO或蒸馏水中的溶液可在-20°下稳定储存3个月。 |
Beta-d-N4-hydroxycytidine is an anti-VEEV (venezuelan equine encephalitis virus) agent with EC 50 , EC 90 , and EC 99 are 0.426, 1.036, and 2.5 μM, respectively.Beta-d-N4-hydroxycytidine inhibits CHIKV replicon activity and the 50% effective concentration (EC 50 ) s 0.8 μM in the Huh-7–CHIKV replicon cell line. Similar results is presented with the replicon in BHK-21 cells (EC 50 =1.8 μM). NHC has no cytotoxicity for NHC in the Huh-7 cell culture system until up to 100 μM using MTT assays. The 50% cytotoxic concentration (CCsub>50) values for NHC are determined to be 30.6 μM, 7.7 μM, and 2.5 μM in peripheral blood mononuclear (PBM), Vero, and CEM cells, respectively.NHC behaves as a pyrimidine analog, NHC-mediated inhibition of the CHIKV replicon can be abrogated by the addition of exogenous nucleosides, such as pyrimidines C and U, but dA, dC, dG, dU, or T has no impact on the replicon. Pyrimidines A and G contributes to replicon inhibition both in the presence and in the absence of NHC.