原苏木素A
| 中文名称 | 原苏木素A |
|---|---|
| 中文同义词 | 原苏木素A;原苏木素A对照品;原苏木素A标准品;3,10,11-三羟基-6H-二苯并[B,D]OXOCIN-7(8H)-酮 |
| 英文名称 | protosappanin A |
| 英文同义词 | protosappanin A;Sappanol B;3,10,11-Trihydroxy-6H-dibenz[b,d]oxocin-7(8H)-one;PROTOSAPPANIN A (PTA);6H-Dibenz[b,d]oxocin-7(8H)-one, 3,10,11-trihydroxy-;3,10,11-Trihydroxy-6H-dibenzo[b,d]oxocin-7(8H)-one;Protosappanin A,inhibit,JAK,Inhibitor,STAT,Janus kinase |
| CAS号 | 102036-28-2 |
| 分子式 | C15H12O5 |
| 分子量 | 272.25 |
| EINECS号 | |
| 相关类别 | 对照品，标准品，含量测定，药理研究;标准品-对照品;标准品，对照品;对照品;其它酚类;标准品，对照品 |
| Mol文件 | 102036-28-2.mol |
| 结构式 |  |
原苏木素A 性质
| 熔点 | 254-255 °C |
|---|---|
| 沸点 | 613.1±55.0 °C(Predicted) |
| 密度 | 1.476±0.06 g/cm3(Predicted) |
| 储存条件 | 4°C, away from moisture and light |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | 9.01±0.20(Predicted) |
|
JAK2
|
STAT3
|
Protosappanin A (PTA: 12.5, 25, 50 μM, 24 hours) significantly inhibits the production of TNF-α and IL-1β in LPS-activated BV2 microglia. And the mRNA expressions of IL-6, IL-1β, and MCP-1 are reduced by PTA in a dose-dependent manner in BV2 microglial cell line.
Protosappanin A (PTA: 12.5, 25, 50 μM, 24 hours) suppresses JAK2/STAT3-dependent inflammation pathway through down-regulating the phosphorylation of JAK2 and STAT3, as well as STAT3 nuclear translocation against LPS treatment.
Protosappanin A (PTA: 12.5, 25, 50 μM, 24 hours) shows obvious effect on disturbing the interaction of transmembrane protein CD14 with Toll-like receptor-4, resulting in the inhibition of NF-κB-dependent oxidative and nitrative stress in LPS-induced BV2 microglia.
Western Blot Analysis
| Cell Line: | Murine BV2 microglial cell line. |
| Concentration: | 12.5, 25, 50 μM. |
| Incubation Time: | 24 hours. |
| Result: |
Inhibits the releases of NO, TNF-α and IL-1β in LPS-induced BV2 cells.
Attenuated IL-6, IL-1β and MCP-1 gene expressions in the LPS-induced BV2 cells. Suppressed JAK2/STAT3 pathway activation in the LPS-induced BV2 cells. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-113573 | 原苏木素A Protosappanin A | 102036-28-2 | 1mg | 1850元 |
| 2024/01/25 | HY-113573 | 原苏木素A Protosappanin A | 102036-28-2 | 5mg | 5500元 |