8-(1,3,4-OXADIAZOL-2-YL)-2,4-BIS(TRIFLUOROMETHYL)IMIDAZO[1,2-A][1,8]NAPHTHYRIDINE
| 中文名称 | 8-(1,3,4-OXADIAZOL-2-YL)-2,4-BIS(TRIFLUOROMETHYL)IMIDAZO[1,2-A][1,8]NAPHTHYRIDINE |
|---|---|
| 中文同义词 | 8-(1,3,4-噁二唑-2-基)-2,4-双(三氟甲基)咪唑并[1,2-Α][1,8]萘啶;2-(2,4-二(三氟甲基)咪唑并[1,2-A][1,8]萘啶-8-基)-1,3,4-恶二唑;化合物RO8191 |
| 英文名称 | 8-(1,3,4-OXADIAZOL-2-YL)-2,4-BIS(TRIFLUOROMETHYL)IMIDAZO[1,2-A][1,8]NAPHTHYRIDINE |
| 英文同义词 | 8-(1,3,4-OXADIAZOL-2-YL)-2,4-BIS(TRIFLUOROMETHYL)IMIDAZO[1,2-A][1,8]NAPHTHYRIDINE;RO8191;Imidazo[1,2-a][1,8]naphthyridine, 8-(1,3,4-oxadiazol-2-yl)-2,4-bis(trifluoromethyl)-;2-[2,4-Bis(trifluoromethyl)imidazo[1,2-a]1,8-naphthyridin-8-yl]-1,3,4-oxadiazole;CDM-3008;RO4948191;HCV,Inhibitor,JAK,Hepatitis C virus,Interferon-alpha/beta receptor,CDM3008,Janus kinase,EMCV,CDM 3008,Tyk2,RO-4948191,RO 4948191,HBV,RO8191,interferon,orally,IFNAR,ISGs,cccDNA,IFNAR1,STAT,inhibit,JAK1,RO-8191,RO 8191,Hepatitis B virus,IFNAR2,imidazonaphthyridine,Interferon-α/β receptor,replicon |
| CAS号 | 691868-88-9 |
| 分子式 | C14H5F6N5O |
| 分子量 | 373.21 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | Mol File |
| 结构式 | ![8-(1,3,4-OXADIAZOL-2-YL)-2,4-BIS(TRIFLUOROMETHYL)IMIDAZO[1,2-A][1,8]NAPHTHYRIDINE 结构式](StructureFile/ChemBookStructure6/GIF/CB2134747.gif) |
8-(1,3,4-OXADIAZOL-2-YL)-2,4-BIS(TRIFLUOROMETHYL)IMIDAZO[1,2-A][1,8]NAPHTHYRIDINE 性质
| 储存条件 | Store at 2-8°C |
|---|---|
| 溶解度 | DMSO 中≤0.1mg/ml；二甲基甲酰胺中≤0.5mg/ml |
| 形态 | 结晶固体 |
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JAK1
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IFNAR2
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RO8191 (CDM-3008) exerts antiviral activity dependent on IFNAR2/JAK1, but is independent of IFNAR1/Tyk2. RO8191, an IFNAR2 agonist, stimulates IFN signals in mice.
RO8191 (0.08, 0.4, 2, 10 μM; for 72 h) strongly suppresses HCV replicon activity at 72 h in a dose-dependent manner. RO8191 reduces levels of the proteins HCV NS3 and NS4A, which are localized mainly in the perinuclear region of the replicon cells.
RO8191 (0.08-10 μM; for 72 h) results in the disappearance of viral proteins such as NS3, NS4A/B, and NS5A/B.
RO8191 (CDM-3008; 30 mg/kg; oral) significantly induces antiviral genes Oas1b, Mx1, and Pkr in the livers of six-week-old C57BL/6J mice.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-W063968 | RO8191 | 1 mg | 500元 | |
| 2024/04/30 | HY-W063968 | 8-(1,3,4-OXADIAZOL-2-YL)-2,4-BIS(TRIFLUOROMETHYL)IMIDAZO[1,2-A][1,8]NAPHTHYRIDINE RO8191 | 691868-88-9 | 10 mg | 1800元 |