| 中文名称 | EPSILON-AMANITIN |
|---|---|
| 中文同义词 | |
| 英文名称 | EPSILON-AMANITIN |
| 英文同义词 | EPSILON-AMANITIN;Cyclo[L-Asp-L-t4Hyp-[(4S)-4-hydroxy-L-Ile-]-6-hydroxy-L-Trp2(1)-Gly-3-methyl-L-Nva-Gly-3-oxomercapto(1)-L-Ala-];α-Amanitin, 1-L-aspartic acid-3-[(4S)-4-hydroxy-L-isoleucine]- |
| CAS号 | 21705-02-2 |
| 分子式 | C39H53N9O14S |
| 分子量 | 903.96 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 21705-02-2.mol |
| 结构式 |  |
EPSILON-AMANITIN 性质
| 密度 | 1.1627 (rough estimate) |
|---|---|
| 折射率 | 1.7400 (estimate) |
ε-Amanitin，从多种蘑菇中分离出的环状肽，可有效与 RNA 聚合酶 II (RNA polymerase II) 结合并抑制其活性。
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Traditional Cytotoxic Agents
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Amatoxin Family includes alpha-Amanitin, beta-Amanitin, gamma-Amanitin, epsilon-Amanitin (ε-Amanitin), Amanullin, Amanullinic acid, Amaninamide, Amanin and Proamanullin. Amatoxins are potent and selective inhibitors of RNA polymerase II, a vital enzyme in the synthesis of messenger RNA (mRNA), microRNA, and small nuclear RNA (snRNA). By inhibiting the synthesis of mRNA, Amatoxins thereby stop cell metabolism by inhibiting transcription and protein biosynthesis, which results in cellular apoptosis. Consequently Amatoxins stop cell growth and proliferation.
类别
有毒物品毒性分级
剧毒急性毒性
腹腔-小鼠LD50:0.3 毫克/公斤; 未名-小鼠 LD50: 0.5 毫克/公斤可燃性危险特性
可燃;燃烧产生有毒氮氧化物和硫氧化物烟雾储运特性
库房通风低温干燥灭火剂
干粉、泡沫、砂土、二氧化碳, 雾状水