苦木素
中文名称 | 苦木素 |
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中文同义词 | 苦木素;苦味素;QUASSIN (~90%);QUASSIN (>95%);苦木苦素,苦木素 |
英文名称 | QUASSIN |
英文同义词 | Picrasa-2,12-diene-1,11,16-trione, 2,12-dimethoxy-;QUASSINPOWDER;QUASSIN;11,16-trione,2,12-dimethoxy-picrasa-12-diene-1;(3aS,6aR,7aS,8S,11aS,11bS,11cS)-1,3a,4,5,6a,7,7a,8,11,11a,11b,11c-dodecahydro-2,10-dimethoxy-3,8,11a;(3As,6ar,7as,8S,11as,11bs,11cs)-1,3A,4,5,6A,7,7A,8,11,11A,11B,11C-dodecahydro-2,10-dimethoxy-3,8,11A,11C-tetramethyldibenzo(de,G)chromene-1,5,11-trione;2,12-Dimethoxypicrasa-2,12-diene-1,11,16-trione;Einecs 200-985-9 |
CAS号 | 76-78-8 |
分子式 | C22H28O6 |
分子量 | 388.45 |
EINECS号 | 200-985-9 |
相关类别 | 植物提取物;标准品;标准品 -中药标准品;二萜;营养强化剂 |
Mol文件 | 76-78-8.mol |
结构式 |
苦木素 性质
熔点 | 222° |
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比旋光度 | D20 +34.5° (c = 5.09 in CHCl3) |
沸点 | 586.3±50.0 °C(Predicted) |
密度 | 1.23±0.1 g/cm3(Predicted) |
储存条件 | -20°C Freezer, Under inert atmosphere |
溶解度 | 可溶于氯仿(少许)、甲醇(少许) |
形态 | 固体 |
颜色 | 白色至类白色 |
旋光性 (optical activity) | +34.520 (c 5.09, CHCl3) |
LogP | 2.220 (est) |
EPA化学物质信息 | Picrasa-2,12-diene-1,11,16-trione, 2,12-dimethoxy- (76-78-8) |
IC50: 0.15 μM ( P. falciparum )
Quassin (Compound 1; 5-25 ng/mL) inhibits both the basal and luteinizing hormone-stimulated testosterone secretion of rat Leydig cells in a dose-dependent fashion.
Quassin (0.1-2.0 mg/kg; oral administration; daily; for 60 days; females albino rats) treatment shows a significant decrease in the weight of the ovary and uterus. And also shows a significant decrease in serum estrogen levels in quassin treated rats. The Quassin treated rats has a significantly decreased mean litter number and weight. Quassin does not adversely affect the weight of the kidney, heart, liver and the body of the rats.
Animal Model: | 35 females albino rats (150-170 g) |
Dosage: | 0.1 mg/kg, 1.0 mg/kg and 2.0 mg/kg |
Administration: | Oral administration; daily; for 60 days |
Result: | There was a significant decrease in the weight of the ovary and uterus in all the groups relative to the control. There was also a significant decrease in serum estrogen levels in quassin treated rats. |