雷得唑来
| 中文名称 | 雷得唑来 |
|---|---|
| 中文同义词 | N-[[(5S)-3-[2-氟-4'-[[(1H-1,2,3-三唑-5-基甲基)氨基]甲基][1,1'-联苯]-4-基]-2-氧代-5-恶唑啉基]甲基]乙酰胺;雷得唑来;雷得唑来RADEZOLID;雷德唑来 |
| 英文名称 | Radezolid |
| 英文同义词 | N-[[(5S)-3-[2-Fluoro-4'-[[(1H-1,2,3-triazol-5-yLmethyl)amino]methyl][1,1'-biphenyl]-4-yl]-2-ox;Unii-53pc6lo35w;RX 1741;RX-1741;radezolid;N-[[(5S)-3-[2-Fluoro-4'-[[(1H-1,2,3-triazol-5-ylmethyl)amino]methyl][1,1'-biphenyl]-4-yl]-2-oxo-5-oxazolidinyl]methyl]acetamide;Radezolid 13C D2 15N;Acetamide, N-[[(5S)-3-[2-fluoro-4'-[[(1H-1,2,3-triazol-5-ylmethyl)amino]methyl][1,1'-biphenyl]-4-yl]-2-oxo-5-oxazolidinyl]methyl]- |
| CAS号 | 869884-78-6 |
| 分子式 | C22H23FN6O3 |
| 分子量 | 438.45 |
| EINECS号 | |
| 相关类别 | 微生物Microbiology |
| Mol文件 | 869884-78-6.mol |
| 结构式 |  |
雷得唑来 性质
| 沸点 | 712.5±60.0 °C(Predicted) |
|---|---|
| 密度 | 1.336 |
| 储存条件 | Store at -20°C |
| 溶解度 | DMSO 中≥43.8 mg/mL；不溶于水；温和加热时，EtOH 中≥18.08 mg/mL |
| 酸度系数(pKa) | 15.53±0.46(Predicted) |
| 形态 | 固体 |
Radezolid (RX-1741) 是一种噁唑烷酮类抗生素。Radezolid 对葡萄球菌，衣原体和军团菌具有活性，对 Linezolid 耐药菌株也具有活性。
Radezolid MICs are systematically equal to or lower (up to 3 log2 dilutions) than those of linezolid for all linezolid-susceptible strains, with an 8-fold difference for the linezolid-resistant strains. Radezolid shows a greater potency than linezolid, independent of the bacteria tested, when concentrations are expressed on a weight (mg/L) basis. Radezolid shows an improved potency compared to that of linezolid when concentrations are expressed on a weight (mg/L) basis. Radezolid and TR-700 perform well against 3-copy G2447T, G2576T, and G2576T/T2571C mutants.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-14800 | Radezolid | 1 mg | 718元 | |
| 2024/01/25 | HY-14800 | 雷得唑来 Radezolid | 869884-78-6 | 5mg | 1581元 |