PANCREATIC POLYPEPTIDE (BOVINE)
| 中文名称 | PANCREATIC POLYPEPTIDE (BOVINE) |
|---|---|
| 中文同义词 | 胰腺多肽,牛 |
| 英文名称 | PANCREATIC POLYPEPTIDE (BOVINE) |
| 英文同义词 | H-Ala-Pro-Leu-Glu-Pro-Glu-Tyr-Pro-Gly-Asp-Asn-Ala-Thr-Pro-Glu-Gln-Met-Ala-Gln-Tyr-Ala-Ala-Glu-Leu-Arg-Arg-Tyr-Ile-Asn-Met-Leu-Thr-Arg-Pro-Arg-Tyr-NH2;PANCREATIC POLYPEPTIDE (BOVINE);Pancreatic polypeptide (pig),6-L-glutamic acid- |
| CAS号 | 179986-89-1 |
| 分子式 | |
| 分子量 | 0 |
| EINECS号 | |
| 相关类别 | 多肽;标准品;目录肽;peptide |
| Mol文件 | Mol File |
| 结构式 |
PANCREATIC POLYPEPTIDE (BOVINE) 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | 溶于二甲基亚砜 |
NPYR4
Pancreatic Polypeptide, bovine is an agonist of NPY receptor, with high affinity at NPYR4. Pancreatic Polypeptide (1 μM) does not alter proliferation in BRIN BD11 or 1.1B4 beta-cells, but reverses the decreased cell viability in BRIN BD11 cells induced by streptozotocin. Pancreatic Polypeptide (0.1 nM-1 μM) shows no effect on insulin secretion from isolated mouse islets, and does not affect the membrane potential and (Ca 2+ ) i levels in BRIN BD11 cells at 1 μM. Pancreatic Polypeptide, bovine inhibits secretin- and cholecystokinin-stimulated pancreatic secretion. 125 I-Pancreatic Polypeptide, bovine shows no specific binding to pancreatic acini.
Pancreatic Polypeptide (25 nmol/kg bw, i.p.) reduces glucose-stimulated insulin concentrations but shows no effect on acute feeding behaviour in overnight fasted mice. Pancreatic Polypeptide, bovine (BPP; 40 μg/kg) inhibits CCK-33-induced pancreatic protein output during the entire bovine Pancreatic Polypeptide infusion period, but shows no effect on biliary protein output during CCK-33 or CCK-8 infusion.