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| | ETHYL PICOLINOYLACETATE Basic information |
| Product Name: | ETHYL PICOLINOYLACETATE | | Synonyms: | Ethyl picolinoylacetate, Ethyl 3-oxo-3-(pyridin-2-yl)propionate, 2-(3-Ethoxy-3-oxopropanoyl)pyridine;Ethyl picolinoylacetate, 95% 2.5GR;Ethyl 3-oxo-3-(2-pyridyl)propionate, 95+%;Ethyl 3-(2-pyridyl)-3-oxopropionate;Ethyl picolinoylacetate,95%;ethyl 3-oxo-3-(2-pyridinyl)propanoate(SALTDATA: FREE);ETHYL PICOLINOYLACETATE;ETHYL 3-OXO-3-(2-PYRIDYL)PROPIONATE | | CAS: | 26510-52-1 | | MF: | C10H11NO3 | | MW: | 193.2 | | EINECS: | | | Product Categories: | | | Mol File: | 26510-52-1.mol |  |
| | ETHYL PICOLINOYLACETATE Chemical Properties |
| Boiling point | 100-104 °C (0.3 mmHg) | | density | 1.164 | | refractive index | 1.516-1.519 | | Fp | 121℃ | | storage temp. | Inert atmosphere,Room Temperature | | pka | 9.37±0.46(Predicted) | | form | Liquid | | color | Clear straw-yellow to brown | | Sensitive | Light Sensitive | | CAS DataBase Reference | 26510-52-1 |
| Hazard Codes | Xi | | Risk Statements | 36 | | Safety Statements | 24/25-22-26 | | Hazard Note | Irritant | | HS Code | 29333990 |
| Provider | Language |
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ACROS
| English |
| | ETHYL PICOLINOYLACETATE Usage And Synthesis |
| Chemical Properties | Clear straw-yellow to brown liquid | | Synthesis | In a 22 L three-necked flask equipped with a reflux condenser tube, a nitrogen introduction tube and a mechanical stirrer, sodium ethoxide (360 g, 5.29 mol), toluene (4 L), ethanol (18 mL, 0.265 mol) and ethyl acetate (1.04 L, 10.6 mol) were added sequentially and stirring was initiated. After stirring for 1 h, the reaction mixture was warmed up to 26 °C. Subsequently, ethyl 2-pyridinecarboxylate (Fluka; 400 g, 2.65 mol) was added to the reaction system and the mixture was heated to reflux (90 °C) and maintained for 18 hours. After completion of the reaction, the mixture was cooled to room temperature, diluted with toluene (8 L) and subsequently washed with deionized water (6 L) and partitioned. The aqueous layer was adjusted to pH 5 with glacial acetic acid and extracted with ethyl acetate (2 x 4 L). The organic layers were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to afford 466 g (91% yield) of the target product ethyl 3-oxo-3-(2-pyridinyl)propionate as a dark-colored oil, with a purity of 93% by HPLC analysis. Mass spectrum (ES+) m/e: 194 ([M+H]+). | | References | [1] Patent: WO2005/92894, 2005, A1. Location in patent: Page/Page column 22
[2] Asian Journal of Chemistry, 2015, vol. 27, # 5, p. 1667 - 1670
[3] Patent: US2007/203154, 2007, A1. Location in patent: Page/Page column 54-55
[4] Helvetica Chimica Acta, 1955, vol. 38, p. 1289
[5] Journal of the American Chemical Society, 1948, vol. 70, p. 2755,2757 |
| | ETHYL PICOLINOYLACETATE Preparation Products And Raw materials |
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