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W-7 HYDROCHLORIDE

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W-7 HYDROCHLORIDE Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:W-7 hydrochloride；W-7 HCl;W 7 HCl;W7 HCl
CAS:61714-27-0
Package:100 mg；200 mg；25 mg；50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Career Henan Chemica Co
Tel: +86-0371-86658258 15093356674;
Email: laboratory@coreychem.com
Products Intro: Product Name:W-7 HYDROCHLORIDE
CAS:61714-27-0
Purity:98.8%min emma@coreychem.com Package:1KG;2.18USD
Company Name: Dayang Chem (Hangzhou) Co.,Ltd.
Tel: 571-88938639 +8617705817739
Email: info@dycnchem.com
Products Intro: Product Name:N-(6-Aminohexyl)-5-Chloro-1-Naphthalenesulfonamide Hydrochloride
CAS:61714-27-0
Purity:0.95&0.99 Package:0.1KG;1KG;1000KG Remarks:Hot selling
Company Name: InvivoChem
Tel: +1-708-310-1919 +1-13798911105
Email: sales@invivochem.cn
Products Intro: Product Name:W-7 HCl
CAS:61714-27-0
Purity:98% Package:50mg Remarks:V12983
Company Name: Hangzhou MolCore BioPharmatech Co.,Ltd.
Tel: +86-057181025280; +8617767106207
Email: sales@molcore.com
Products Intro: Product Name:W 7 (hydrochloride)
CAS:61714-27-0
Purity:NLT 98% Remarks:MC563613
W-7 HYDROCHLORIDE Basic information
Product Name:W-7 HYDROCHLORIDE
Synonyms:OMEGA-7 HYDROCHLORIDE;N-(6-AMINOHEXYL)-5-CHLORONAPHTHALENE-1-SULFONAMIDE HYDROCHLORIDE;N-(6-AMINOHEXYL)-5-CHLORO-1-NAPHTHALENESULFONAMIDE HCL;N-(6-AMINOHEXYL)-5-CHLORO-1-NAPHTHALENESULFONAMIDE HYDROCHLORIDE;N-(6-AMINOHEXYL)-5-CHLORO-1-NAPHTHALENESULPHONAMIDE HYDROCHLORIDE;W-7;W-7 HYDROCHLORIDE;N-(6-Aminohexyl)-5-chloronaphthalene-1-sulphonamide hydrochloride
CAS:61714-27-0
MF:C16H22Cl2N2O2S
MW:377.33
EINECS:
Product Categories:All Inhibitors;Inhibitors;Protein Kinase Inhibitors and Activators;Calcium signaling
Mol File:61714-27-0.mol
W-7 HYDROCHLORIDE Structure
W-7 HYDROCHLORIDE Chemical Properties
Melting point 220-222 °C
storage temp. -20°C
solubility methanol: 25 mg/mL, clear, colorless
form Off-white crystalline solid
color White to Off-White
BRN 6030174
CAS DataBase Reference61714-27-0(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Safety Statements 22-24/25
WGK Germany 3
RTECS QK0786000
F 3-10
HS Code 2935909099
MSDS Information
ProviderLanguage
SigmaAldrich English
W-7 HYDROCHLORIDE Usage And Synthesis
DescriptionCalmodulin is a calcium-dependent protein that regulates the activity of a diverse array of enzymes, ion channels, and other proteins and thus has diverse roles in cell function. W-7 is a cell-permeable antagonist of calmodulin (Ki = 11 μM). Two molecules of W-7 bind to calcium-binding domains in each calmodulin molecule, blocking its interaction with target proteins. W-7 also associates, at lower affinities, with calcium-binding domains of other proteins, including troponin C and myosin light chain kinase (Ki = 70 and 300 μM, respectively).
Chemical PropertiesWhite Crystalline Solid
UsesN-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride has been used to study its effect of on coated pit staining.
UsesW7 is a vascular relaxing agent which affects vascular smooth muscle actomyosin. W7, an inhibitor of actomyosin superprecipitation, produces relaxation of isolated rabbit arterial strips and antagonizes the contraction of the strips induced by various contractile agonists. W7 is also a calmodulin antagonist that binds to calmodulin and inhibits Ca2+/calmodulin-regulated enzyme activities.
General DescriptionA cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC50 = 51 μM) and Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 28 μM).
Biological ActivityCalmodulin antagonist. Inhibits Ca 2+ -calmodulin-dependent phosphodiesterase (IC 50 = 28 μ M) and myosin light chain kinase (IC 50 = 51 μ M).
Biochem/physiol ActionsCell permeable: yes
storageStore at RT
W-7 HYDROCHLORIDE Preparation Products And Raw materials
Tag:W-7 HYDROCHLORIDE(61714-27-0) Related Product Information
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