| 公司名称： |
上海复和化学科技有限公司 |
| 联系电话： |
0086-21-67651709 |
| 产品介绍： |
中文名称：盐酸阿柔比星
英文名称：Aclarubicin HCl
CAS：75443-99-1
|
| 公司名称： |
BOC Sciences |
| 联系电话： |
16314854226 |
| 产品介绍： |
英文名称：Aclarubicin hydrochloride
CAS：75443-99-1
纯度：>98% 包装信息：$499/5mg 备注：aclarubicin is an oligosaccharide anthracycline antineoplastic antibiotic isolated from the bacterium Streptomyces galilaeus. Aclarubicin intercalates into DNA and interacts with topoisomerases I and |
| 公司名称： |
上海瀚香生物科技有限公司 |
| 联系电话： |
17754423994 17754423994 |
| 产品介绍： |
中文名称：盐酸阿柔比星; 阿柔比星盐酸盐
英文名称：Aclarubicin Hydrochloride
CAS：75443-99-1
纯度：98% HPLC LCMS 包装信息：100mg;1g |
| 公司名称： |
范德(北京)生物科技有限责任公司 |
| 联系电话： |
15911056312 |
| 产品介绍： |
中文名称：盐酸阿柔比星
英文名称：ACLARUBICIN HYDROCHLORIDE
CAS：75443-99-1
纯度：97.0% 包装信息：5mg 备注：见官网产品说明 |
| 公司名称： |
台州市科瑞生物技术有限公司 |
| 联系电话： |
0576-88813233 13396860566 |
| 产品介绍： |
中文名称：阿柔比星盐酸盐
英文名称：Aclarubicin hydrochloride
CAS：75443-99-1
纯度：98% min 包装信息：1g/ |
|
| 中文名称: | 盐酸阿柔比星 | | 中文同义词: | 盐酸阿柔比星;阿柔比星盐酸盐 | | 英文名称: | ACLARUBICIN HYDROCHLORIDE | | 英文同义词: | aclacinomycinahydrochloride;aclacinon;n-2-yl)-alpha-l-lyxo-hexopyranosyl)-3-(dimethylamino)-alpha-l-lyxo-hexopyrano;syl)oxy)-2,5,7-trihydroxy-,methylester,hydrochloride,(1r-(1-alpha,2-beta,4;1-Naphthacenecarboxylic acid, 2-ethyl-1,2,3,4,6,11-hexahydro-2,5,7-trihydroxy-6,11-dioxo-4-[[2,3,6-trideoxy-4-O-[2,6-dideoxy-4-O-[(2R-trans)-tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl]-alpha-l-lyxo-hexopyranosyl]-3-(dimethylamino)-alpha-l-lyxo;ACLARUBICIN HYDROCHLORIDE;1-Naphthacenecarboxylic acid, 2-ethyl-1,2,3,4,6,11-hexahydro-2,5,7-trihydroxy-6,11-dioxo-4-[[2,3,6-trideoxy-4-O-[2,6-dideoxy-4-O-[(2R,6S)-tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl]-α-L-lyxo-hexopyranosyl]-3-(dimethylamino)-α-L-lyxo-hexopyranosyl]oxy]-, meth;1-Naphthacenecarboxylic acid, 2-ethyl-1,2,3,4,6,11-hexahydro-2,5,7-trihydroxy-6,11-dioxo-4-[[2,3,6-trideoxy-4-O-[2,6-dideoxy-4-O-[(2R-trans)-tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl]-α-L-lyxo-hexopyranosyl]-3-(dimethylamino)-α-L-lyxo-hexopyranosyl]oxy]-, methyl ester, hydrochloride, [1R-(1α,2β,4β)]- | | CAS号: | 75443-99-1 | | 分子式: | C42H54ClNO15 | | 分子量: | 848.33 | | EINECS号: | 278-209-3 | | 相关类别: | API | | Mol文件: | 75443-99-1.mol |  |
| 熔点 | 151-153℃ | | 沸点 | 898℃ | | 闪点 | >110°(230°F) | | 储存条件 | 2-8°C | | 溶解度 | Soluble in DMSO or DMF at 25mg/ml |
| 生物活性 | Aclacinomycin A hydrochloride (Aclarubicin hydrochloride) 是一种荧光分子，是第一个发现对 20S 蛋白酶体 (20S proteasome) 的 CTRL (糜凝乳蛋白酶样) 活性具有离散特异性的非肽性抑制剂。同时也是 拓扑异构酶 I 和 II (topoisomerase I and II) 的双抑制剂。是一种有效蒽环类化疗试剂用于血癌和实体肿瘤的相关研究。 | | 靶点 |
20S proteasome.
Topoisomerase I and II.
| | 体外研究 |
Aclacinomycin A could efficiently enter living cells and emit fluorescence
in situ
. Aclacinomycin A (10 μM for 15 min) is sufficient for clear detection of fluorescence in most of the cultured cells. Aclacinomycin A treatment (10 μM Acla for 15 min) results in approximately 20% dead (or nearly dead) cells.
Aclacinomycin A (Aclarubicin) effectively induces incorporation of exon 7 into SMN2 transcripts from the endogenous gene in type I SMA fibroblasts as well as into transcripts from a SMN2 minigene in the motor neuron cell line NSC34 .
| | 体内研究 |
Aclacinomycin A is very well absorbed in mice, rats, and dogs after its oral administration. The oral LD
50
(76.5 mg/kg) is about twice the iv LD
50
(35.6 mg/kg) in mice
[4
.
Aclacinomycin A (0.75-6 mg/kg, ip daily) dose-dependently exhibits tumor growth in mice-based Leukemia P-388 model
[4
.
|
Animal Model:
|
DBA/2, CDF
1
(BALB/c×DBA/2) mice with Leukemia P-388
[4
.
|
|
Dosage:
|
0.75 mg/kg, 1.5 mg/kg, 3 mg/kg, 6 mg/kg.
|
|
Administration:
|
Intraperitoneal administration daily for 10 days starting 3 hr after transplantation.
|
|
Result:
|
Inhibited tumor growth.
|
|
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 | | 2022/07/01 | HY-N2306A | 盐酸阿柔比星
Aclacinomycin A hydrochloride | 75443-99-1 | 5mg | 2800元 | | | 2022/07/01 | HY-N2306A | Aclacinomycin A hydrochloride | | 10 mM * 1 mLin DMSO | 4479元 | |
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