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盐酸阿柔比星

盐酸阿柔比星 更多供应商
公司名称: 上海复和化学科技有限公司  
联系电话: 0086-21-67651709
产品介绍: 中文名称:盐酸阿柔比星
英文名称:Aclarubicin HCl
CAS:75443-99-1
公司名称: BOC Sciences  
联系电话: 16314854226
产品介绍: 英文名称:Aclarubicin hydrochloride
CAS:75443-99-1
纯度:>98% 包装信息:$499/5mg 备注:aclarubicin is an oligosaccharide anthracycline antineoplastic antibiotic isolated from the bacterium Streptomyces galilaeus. Aclarubicin intercalates into DNA and interacts with topoisomerases I and
公司名称: 上海瀚香生物科技有限公司  
联系电话: 17754423994 17754423994
产品介绍: 中文名称:盐酸阿柔比星; 阿柔比星盐酸盐
英文名称:Aclarubicin Hydrochloride
CAS:75443-99-1
纯度:98% HPLC LCMS 包装信息:100mg;1g
公司名称: 范德(北京)生物科技有限责任公司  
联系电话: 15911056312
产品介绍: 中文名称:盐酸阿柔比星
英文名称:ACLARUBICIN HYDROCHLORIDE
CAS:75443-99-1
纯度:97.0% 包装信息:5mg 备注:见官网产品说明
公司名称: 台州市科瑞生物技术有限公司  
联系电话: 0576-88813233 13396860566
产品介绍: 中文名称:阿柔比星盐酸盐
英文名称:Aclarubicin hydrochloride
CAS:75443-99-1
纯度:98% min 包装信息:1g/
最新发布供应信息
阿柔比星盐酸盐_台州市科瑞生物技术有限公司
2022/4/16 7:56:45
盐酸阿柔比星
生物活性靶点体外研究体内研究 MSDS 用途与合成方法 盐酸阿柔比星价格(试剂级) 上下游产品信息
中文名称:盐酸阿柔比星
中文同义词:盐酸阿柔比星;阿柔比星盐酸盐
英文名称:ACLARUBICIN HYDROCHLORIDE
英文同义词:aclacinomycinahydrochloride;aclacinon;n-2-yl)-alpha-l-lyxo-hexopyranosyl)-3-(dimethylamino)-alpha-l-lyxo-hexopyrano;syl)oxy)-2,5,7-trihydroxy-,methylester,hydrochloride,(1r-(1-alpha,2-beta,4;1-Naphthacenecarboxylic acid, 2-ethyl-1,2,3,4,6,11-hexahydro-2,5,7-trihydroxy-6,11-dioxo-4-[[2,3,6-trideoxy-4-O-[2,6-dideoxy-4-O-[(2R-trans)-tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl]-alpha-l-lyxo-hexopyranosyl]-3-(dimethylamino)-alpha-l-lyxo;ACLARUBICIN HYDROCHLORIDE;1-Naphthacenecarboxylic acid, 2-ethyl-1,2,3,4,6,11-hexahydro-2,5,7-trihydroxy-6,11-dioxo-4-[[2,3,6-trideoxy-4-O-[2,6-dideoxy-4-O-[(2R,6S)-tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl]-α-L-lyxo-hexopyranosyl]-3-(dimethylamino)-α-L-lyxo-hexopyranosyl]oxy]-, meth;1-Naphthacenecarboxylic acid, 2-ethyl-1,2,3,4,6,11-hexahydro-2,5,7-trihydroxy-6,11-dioxo-4-[[2,3,6-trideoxy-4-O-[2,6-dideoxy-4-O-[(2R-trans)-tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl]-α-L-lyxo-hexopyranosyl]-3-(dimethylamino)-α-L-lyxo-hexopyranosyl]oxy]-, methyl ester, hydrochloride, [1R-(1α,2β,4β)]-
CAS号:75443-99-1
分子式:C42H54ClNO15
分子量:848.33
EINECS号:278-209-3
相关类别:API
Mol文件:75443-99-1.mol
盐酸阿柔比星
盐酸阿柔比星 性质
熔点 151-153℃
沸点 898℃
闪点 >110°(230°F)
储存条件 2-8°C
溶解度 Soluble in DMSO or DMF at 25mg/ml
盐酸阿柔比星 用途与合成方法
生物活性Aclacinomycin A hydrochloride (Aclarubicin hydrochloride) 是一种荧光分子,是第一个发现对 20S 蛋白酶体 (20S proteasome) 的 CTRL (糜凝乳蛋白酶样) 活性具有离散特异性的非肽性抑制剂。同时也是 拓扑异构酶 I 和 II (topoisomerase I and II) 的双抑制剂。是一种有效蒽环类化疗试剂用于血癌和实体肿瘤的相关研究。
靶点

20S proteasome.
Topoisomerase I and II.

体外研究

Aclacinomycin A could efficiently enter living cells and emit fluorescence in situ . Aclacinomycin A (10 μM for 15 min) is sufficient for clear detection of fluorescence in most of the cultured cells. Aclacinomycin A treatment (10 μM Acla for 15 min) results in approximately 20% dead (or nearly dead) cells.
Aclacinomycin A (Aclarubicin) effectively induces incorporation of exon 7 into SMN2 transcripts from the endogenous gene in type I SMA fibroblasts as well as into transcripts from a SMN2 minigene in the motor neuron cell line NSC34 .

体内研究

Aclacinomycin A is very well absorbed in mice, rats, and dogs after its oral administration. The oral LD 50 (76.5 mg/kg) is about twice the iv LD 50 (35.6 mg/kg) in mice [4 .
Aclacinomycin A (0.75-6 mg/kg, ip daily) dose-dependently exhibits tumor growth in mice-based Leukemia P-388 model [4 .

Animal Model: DBA/2, CDF 1 (BALB/c×DBA/2) mice with Leukemia P-388 [4 .
Dosage: 0.75 mg/kg, 1.5 mg/kg, 3 mg/kg, 6 mg/kg.
Administration: Intraperitoneal administration daily for 10 days starting 3 hr after transplantation.
Result: Inhibited tumor growth.
安全信息
危险品标志 T
危险类别码 23/24/25
安全说明 36/37/39-45
危险品运输编号 3249
RTECS号QI9283500
HazardClass 6.1(a)
PackingGroup II
盐酸阿柔比星 化学药品说明书
注射用盐酸阿柔比星
盐酸阿柔比星 价格(试剂级)
更新日期产品编号产品名称CAS编号包装价格
2022/07/01HY-N2306A盐酸阿柔比星
Aclacinomycin A hydrochloride
75443-99-15mg2800元
2022/07/01HY-N2306AAclacinomycin A hydrochloride10 mM * 1 mLin DMSO4479元
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