河豚毒素鹼 基本信息
| 中文名称 | 河豚毒素鹼 |
|---|---|
| 中文同义词 | 河豚毒素鹼;河豚毒素柠檬酸酯盐 |
| 英文名称 | TETRODOTOXIN CITRATE |
| 英文同义词 | TETRODOTOXIN;TETRODOTOXIN CITRATE;OCTAHYDRO-12-(HYDROXYMETHYL)-2-IMINO-5,9:7,10A-DIMETHANO-10AH-[1,3]DIOXOCINO[6,5-D]PYRIMIDINE-4,7,10,11,12-PENTOL CITRATE;citratodetetrodotoxina;tetrodotoxin,citrate(1:1)(salt);Octahydro-12-(hydroxymethyl)-2-imino-5,9:7,10a-dimethano-10aH-[1,3]dioxocino[6,5-d]pyrimidine-4,7,10,11,12-pentolcitrat;Citrato de tetrodotoxina [spanish];Tetrodotoxin, 2-hydroxy-1,2,3-propanetricarboxylate (1:1) (salt) (9ci) |
| CAS号 | 18660-81-6 |
| 分子式 | C17H25N3O15 |
| 分子量 | 511.39 |
| EINECS号 | 689-001-0 |
| 相关类别 | Sodium channel |
| Mol文件 | 18660-81-6.mol |
| 结构式 |  |
河豚毒素鹼 性质
| 储存条件 | Desiccate at -20°C |
|---|---|
| 溶解度 | 柠檬酸盐缓冲液 (pH 4.8)：30 mg/ml (100 mM) |
| 形态 | 固体 |
| 酸度系数(pKa) | 8.76(at 25℃) |
| 水溶解性 | Soluble to 100 mM in water |
| 稳定性 | 在酸性溶液中不稳定 |
安全信息
| 危险品标志 | T+ |
|---|---|
| 危险类别码 | 26/27/28 |
| 安全说明 | 22-36/37/39-45 |
| RTECS号 | IO1450000 |
| 毒性 | A toxin contained in the ovary and liver of puffer fish, in the eggs of the California newt and in some other animals. It is used as a chemical tool for the study of ion channels. The s.c. LD50 in mice is 10 mg/kg. It is a toxicant of nerve and muscle by blocking sodium channels, this action causing nerve and muscle paralysis. Symptoms include weakening of voluntary muscles, respiratory failure from paralysis of the diaphragm and hypotension. There is no antidote. Therapy involves artificial respiration. |