(-)-INDOLACTAM V

(-)-INDOLACTAM V Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:(-)-Indolactam V;Indolactam V
CAS:90365-57-4
Package:1 mg;1 mL * 10mM (in DMSO);10 mg;5 mg;50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Finetech Industry Limited
Tel: +86-27-87465837 +8618971612321
Email: info@finetechnology-ind.com
Products Intro: Product Name:()-Indolactam V
CAS:90365-57-4
Purity:98% Package:1g,10g,25g,500g,1kg Remarks:N/A
Company Name: 3B Pharmachem (Wuhan) International Co.,Ltd.  
Tel: 821-50328103-801 18930552037
Email: 3bsc@sina.com
Products Intro: Product Name:(-)-IndolactaM V;(2S,5S)-1,2,4,5,6,8-Hexahydro-5-(hydroxyMethyl)-1-Methyl-2-(1-Methylethyl)-3H-pyrrolo[4,3,2-gh]-1,4-benzodiazonin-3-one
CAS:90365-57-4
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
Company Name: Haoyuan Chemexpress Co., Ltd.  
Tel: 021-58950125
Email: info@chemexpress.com
Products Intro: Product Name:(-)-Indolactam V
CAS:90365-57-4
Purity:>98% Package:1800RMB/1mg
Company Name: Sichuan Wei Keqi Biological Technology Co., Ltd.  
Tel: 028-81700200 18116577057
Email: 3003855609@qq.com
Products Intro: Product Name:(-)-Indolactam V
CAS:90365-57-4
Purity:≥98% Package:20mg/10
(-)-INDOLACTAM V Basic information
Product Name:(-)-INDOLACTAM V
Synonyms:(2s-(2r*,5r*))-ethyl)-1-methyl-2-(1-methylethyl);3h-pyrrolo(4,3,2-gh)-1,4-benzodiazonin-3-one,1,2,4,5,6,8-hexahydro-5-(hydroxym;(-)-INDOLACTAM V;(2S,5S)-1,2,4,5,6,8-Hexahydro-5-(hydroxymethyl)-1-methyl-2-(1-methylethyl)-3H-pyrrolo[4,3,2-gh]-1,4-benzodiazonin-3-one;(-)-Ilv;3H-Pyrrolo(4,3,2-gh)-1,4-benzodiazonin-3-one, 1,2,4,5,6,8-hexahydro-5-(hydroxymethyl)-1-methyl-2-(1-methylethyl)-, (2S-(2R*,5R*))-;3H-Pyrrolo(4,3,2-gh)-1,4-benzodiazonin-3-one, 1,2,4,5,6,8-hexahydro-5-(hydroxymethyl)-1-methyl-2-(1-methylethyl)-, (2S,5S)-;Brn 4711877
CAS:90365-57-4
MF:C17H23N3O2
MW:301.38
EINECS:
Product Categories:
Mol File:90365-57-4.mol
(-)-INDOLACTAM V Structure
(-)-INDOLACTAM V Chemical Properties
Boiling point 584.0±50.0 °C(Predicted)
density 1.166±0.06 g/cm3(Predicted)
storage temp. -20°C
solubility DMSO: >10mg/mL, clear
form white powder
pka14.39±0.10(Predicted)
Stability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
Safety Information
WGK Germany 3
RTECS UY8547000
MSDS Information
(-)-INDOLACTAM V Usage And Synthesis
DescriptionIndolactam V (-) (90365-57-4) is a PKC activator acting at the phorbol ester binding site.1,2?Directs differentiation of human and mouse ESCs to pancreatic cells.3?? May be used, along with other agents, to differentiate human iPS cells into glucose-responsive insulin-secreting progeny.4?Increases regulator of G protein signaling 2 (RGS2) protein levels, a protein that regulates GPCR signaling.5
Uses(-)-Indolactam V is an indole alkaloid compound which activates protein kinase C (PKC). Weak tumor promoter. Also directs differentiation of human embryonic stem cells, potentially into pancreatic lineage allowing for an effective diabetes therapy.
DefinitionChEBI: (-)-indolactam V is a 9-membered ring that is a potent protein kinase C activator
Biological ActivityProtein kinase C activator. Exhibits tumor promoting activity. Directs differentiation of human embryonic stem cells (ESCs) into pancreatic progenitors.
Biochem/physiol Actions(-)-Indolactam V is a PKC activator shown to effect differentiation in embryonic stem cells leading to development of pancreatic precursors. It is active in the mouse model.
storage-20°C (desiccate)
References1) Fujiki?et al.?(1984),?Structure-activity studies on synthetic analogues (indolactams) of the tumor promoter teleocidin; Gan., 75?866 2) Heikkila and Ackerman (1989),?(-)-Indolactam V activates protein kinase C and induces changes in muscarinic receptor functions in SH-SY5Y human neuroblastoma cells; Biochem. Biophys. Res. Commun,?162?1207 3) Chen?et al.?(2009),?A small molecule that directs differentiation of human ESCs into the pancreatic lineage; Nat. Chem. Biol.,?5?258 4) Thalava?et al. (2011),?Indolactam V/GLP-1-mediated differentiation of human iPS cells into glucose-responsive insulin-secretin progeny; Gene Ther.,?18?283 5) Raveh (2014),?Identification of protein kinase C activation as a novel mechanism for RGS2 protein upregulation through phenotypic screening of natural product extracts; Mol. Pharmacol.,?86?406
(-)-INDOLACTAM V Preparation Products And Raw materials
Tag:(-)-INDOLACTAM V(90365-57-4) Related Product Information
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