BIOLIMUS A9
| 中文名称 | BIOLIMUS A9 |
|---|---|
| 中文同义词 | 42-O-(2-乙氧基乙基)雷帕霉素;比奥利默斯;化合物 T26309 |
| 英文名称 | UMiroliMus |
| 英文同义词 | BioliMus;BioliMus, BioliMus A9, TRM 986;BIOLIMUS A9;UMiroliMus;Rapamycin, 42-O-(2-ethoxyethyl)-;BioliMus A9 UMiroliMus;TRM 986;TRM986 |
| CAS号 | 851536-75-9 |
| 分子式 | C55H87NO14 |
| 分子量 | 986.28 |
| EINECS号 | |
| 相关类别 | 微生物代谢物;Immunosuppressant;API |
| Mol文件 | 851536-75-9.mol |
| 结构式 |  |
BIOLIMUS A9 性质
| 沸点 | 991.0±75.0 °C(Predicted) |
|---|---|
| 密度 | 1.15±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | DMF：可溶； DMSO：可溶；乙醇：可溶；甲醇：可溶 |
| 形态 | 固体 |
| 酸度系数(pKa) | 10.40±0.70(Predicted) |
Umirolimus is a macrocyclic triene lactone, developed with pharmacological properties specifically tailored for localized drug delivery. Umirolimus can be used drug-eluting stent (DES) applications. Owing to its enhanced lipophilicity,it is strongly attracted to binding sites within the vessel wall and small, tortuous vessels, and contributing to cellular absorption and sustained distribution in the vessel wall surrounding the stent.
Umirolimus prevents progression of the cell cycle in G1 phase by inhibiting IL-2/mTOR-mediated P70-KD S6 protein kinase activation. Umirolimus inhibits T-cell growth, as well as smooth muscle cell growth.
The elimination half-life of Umirolimus is approximately 25 h in whole blood.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-122402 | Umirolimus | 1 mg | 1363元 | |
| 2024/01/25 | HY-122402 | BIOLIMUS A9 Umirolimus | 851536-75-9 | 5mg | 3000元 |