BAY38-7271
| 中文名称 | BAY38-7271 |
|---|---|
| 中文同义词 | (R)-3-(2-(羟甲基)-2,3-二氢-1H-茚-4-氧基)苯基 4,4,4-三氟丁烷-1-磺酸盐;化合物 T14504;化合物 BAY 38-7271 |
| 英文名称 | (R)-3-(2-(hydroxymethyl)-2,3-dihydro-1H-inden-4-yloxy)phenyl 4,4,4-trifluorobutane-1-sulfonate |
| 英文同义词 | (R)-3-(2-(hydroxymethyl)-2,3-dihydro-1H-inden-4-yloxy)phenyl 4,4,4-trifluorobutane-1-sulfonate;BAY 38-7271;KN 38-7271;O-1861 (R-form);BAY-38-7071;1-Butanesulfonic acid, 4,4,4-trifluoro-,3-[[(2R)-2,3-dihydro-2-(hydroxyMethyl)-1H-inden-4-yl]oxy]phenyl ester;4,4,4-Trifluoro-1-butanesulfonic acid 3-[[(2R)-2,3-dihydro-2-(hydroxymethyl)-1H-inden-4-yl]oxy]phenyl ester;(R)-3-(2-(hydroxymethyl)-2,3-dihydro-1H-inden-4-yloxy)phenyl 4,4,4-trifluorobutane-1-sulfonate USP/EP/BP |
| CAS号 | 212188-60-8 |
| 分子式 | C20H21F3O5S |
| 分子量 | 430.4379496 |
| EINECS号 | |
| 相关类别 | Pharmaceutical intermediate |
| Mol文件 | 212188-60-8.mol |
| 结构式 |  |
BAY38-7271 性质
| 沸点 | 527.2±50.0 °C(Predicted) |
|---|---|
| 密度 | 1.350±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 酸度系数(pKa) | 14.81±0.10(Predicted) |
|
CB1 1.85 nM (Ki) |
CB2 5.96 nM (Ki) |
BAY 38-7271 shows only minor interactions at the micromolar range with other binding sites such as adenosine A
3
receptor (IC
50
= 7.5 μM), peripheral GABA
A
benzodiazepine receptor (IC
50
= 971 nM), melatonin ML
1
receptor (IC
50
= 3.3 μM), and at the monoamine transporter (IC
50
= 1.7 μM).
BAY 38-7271 (Ed
50
= 0.02 mg/kg; i.v. and 0.5 mg/kg; i.p.) induces a potent and dose-de-pendent reduction in core body temperature.
BAY 38-7271 has low physical dependence liability and is not essentially different from that of other cannabinoid CB
1
receptor agonists.
BAY 38-7271 (1-1000 ng/kg/h; i.v. infusion; for 4 hours) shows neuroprotective efficacy in the rat SDH model.
BAY 38-7271 also has neuroprotective efficacy in models of transient and permanent occlusion of the middle cerebral artery and brain edema models.
| Animal Model: | Wistar rat ,TBI rat models (acute subdural hematoma, SDH) |
| Dosage: | 1 ng/kg/h, 10 ng/kg/h, 100 ng/kg/h, 1000 ng/kg/h |
| Administration: | Intravenous infusion, for 4 hours |
| Result: | Reduced the mean infarct volume. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025/02/08 | HY-119744 | BAY38-7271 BAY 38-7271 | 212188-60-8 | 1 mg | 5400元 |
| 2023/03/20 | HY-119744 | BAY38-7271 BAY 38-7271 | 212188-60-8 | 5mg | 5800元 |