2-氯-N-[(1R)-1-(3-甲氧基苯基)乙基]苯丙胺盐酸盐 CAS#: 177172-49-5

2-氯-N-[(1R)-1-(3-甲氧基苯基)乙基]苯丙胺盐酸盐

生物活性体外研究体内研究用途与合成方法 MSDS 2-氯-N-[(1R)-1-(3-甲氧基苯基)乙基]苯丙胺盐酸盐价格(试剂级) 上下游产品信息

中文名称	2-氯-N-[(1R)-1-(3-甲氧基苯基)乙基]苯丙胺盐酸盐
中文同义词	2-氯-N-[(1R)-1-(3-甲氧基苯基)乙基]苯丙胺盐酸盐;化合物 T13918;R-568 盐酸盐
英文名称	2-Chloro-N-[(1R)-1-(3-methoxyphenyl)ethyl]-benzenepropanaminehydrochloride
英文同义词	2-Chloro-N-[(1R)-1-(3-methoxyphenyl)ethyl]-benzenepropanaminehydrochloride;R 568 hydrochloride;Tecalcet (Hydrochloride);R-568;Tecalcet HCl (KRN568;NPS-R568;R-568 hydrochloride >=95% (HPLC);Benzenepropanamine, 2-chloro-N-[(1R)-1-(3-methoxyphenyl)ethyl]-, hydrochloride (1:1)
CAS号	177172-49-5
分子式	C18H23Cl2NO
分子量	340.28732
EINECS号
相关类别
Mol文件	177172-49-5.mol
结构式

2-氯-N-[(1R)-1-(3-甲氧基苯基)乙基]苯丙胺盐酸盐性质

熔点	183.3-184.4 °C
储存条件	Inert atmosphere,Room Temperature
溶解度	DMSO：50 mg/mL（146.93 mM；需要超声波）
形态	粉末

2-氯-N-[(1R)-1-(3-甲氧基苯基)乙基]苯丙胺盐酸盐用途与合成方法

生物活性

Tecalcet Hydrochloride (R 568 Hydrochloride) 是一个口服有效的拟钙剂，变构正调控钙敏感受体 (CaSR)。Tecalcet Hydrochloride (R 568 Hydrochloride) 可提高激活细胞外Ca2+的敏感性。

体外研究

Tecalcet (NPS 568, 0.1-100 μM) increase [Ca ²⁺ ]i in a concentrationdependent and stereoselective manner.
Tecalcet (NPS 568, 0.1-100 nM) shiftes the concentration-response curve for extracellular Ca ²⁺ to the left without affecting the maximal response and, thereby, decreases the EC ₅₀ value for extracellular Ca21 to 0.61±0.04 mM.

体内研究

Tecalcet (1.5 and 15 mg/kg, orally, twice daily for 4 days) inhibits PT cell proliferation in rats with renal insufficiency.

Animal Model:	10-wk-old Male Sprague-Dawley rats weighing 310-350 g.
Dosage:	1.5 and 15 mg/kg.
Administration:	Orally twice daily for 4 days.
Result:	Did not significantly change serum 1,25 (OH) ₂ D ₃ levels. In contrast, serum PTH levels were reduced by in a dose-dependent manner. Clearly reduced the number of BrdU-positive PT cells by 20% at a low dose (1.5 mg/kg body wt), and by 50% at a high dose (15 mg/kg body wt), indicating an antiproliferative effect on PT cells. Reduced PT cell volume in a dose-dependent manner.

安全信息

MSDS信息

2-氯-N-[(1R)-1-(3-甲氧基苯基)乙基]苯丙胺盐酸盐价格(试剂级)

更新日期	产品编号	产品名称	CAS号	包装	价格
2024/04/30	HY-10167A	Tecalcet Hydrochloride		1 mg	335元
2024/04/30	HY-10167A	2-氯-N-[(1R)-1-(3-甲氧基苯基)乙基]苯丙胺盐酸盐 Tecalcet Hydrochloride	177172-49-5	5mg	1450元

2-氯-N-[(1R)-1-(3-甲氧基苯基)乙基]苯丙胺盐酸盐