恩曲他滨S-氧化物(非对映体混合物)
中文名称 | 恩曲他滨S-氧化物(非对映体混合物) |
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中文同义词 | 恩曲他滨S-氧化物(非对映体混合物);恩曲他滨 S-氧化物;(2R,3R,5S)-5-氟-1-[2-羟甲基-3-氧-1,3-氧硫环-5-基]胞嘧啶;恩曲他滨杂质II;恩曲他滨亚砜;恩曲他滨杂质 II(恩曲他滨氧化杂质);恩曲他滨 S-氧化物[干冰运输];化合物 T11189 |
英文名称 | (-)-EMtricitabine S-Oxide (Mixture of DiastereoMers) |
英文同义词 | (-)-EMtricitabine S-Oxide (Mixture of DiastereoMers);Emtricitabine Impurity;[2R-(2α,5α)]-4-AMino-5-fluoro-1- [2-(hydroxyMethyl)-3-oxido-1,3-oxathiolan-5-yl]-2(1H)-pyriMidinone;[2R-(2α,5α)]-4-AMino-5-fluoro-1-[2-(hydroxyMethyl) -1,3-oxathiolan-5-yl]-2(1H)-pyriMidinone S-Oxide;4-AMino-5-fluoro-1-[(2R,5S)-2-(hydroxyMethyl)-3-oxido-1,3-oxathiolan-5-yl]-2(1H)-pyriMidinone;Emtricitabine Sulphoxide;2(1H)-Pyrimidinone, 4-amino-5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-3-oxido-1,3-oxathiolan-5-yl]-;Emtricitabine Degradant-III |
CAS号 | 152128-77-3 |
分子式 | C8H10FN3O4S |
分子量 | 263.2461032 |
EINECS号 | |
相关类别 | 杂质;Carbohydrates & Derivatives;Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Sulfur & Selenium Compounds |
Mol文件 | 152128-77-3.mol |
结构式 |
恩曲他滨S-氧化物(非对映体混合物) 性质
熔点 | 212-213°C (dec.) |
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沸点 | 562.8±60.0 °C(Predicted) |
密度 | 2.02±0.1 g/cm3(Predicted) |
储存条件 | Refrigerator |
溶解度 | 甲醇(微溶、加热、超声处理)、水(微溶、加热) |
酸度系数(pKa) | 13.46±0.10(Predicted) |
形态 | 固体 |
颜色 | 白色至类白色 |
HIV
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Reverse Transcriptase
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Emtricitabine, an antiretroviral agent is used to evaluate degradation pathways under different stress conditions in order to identify degradation products as prescribed by ICH guidelines. Emtricitabine degrades over 51%, 13% and 53% during acid, base and oxidative degradation respectively followed by formation of three major degradation products (Degradant-I to Degradant-III).