SOBETIROME
| 中文名称 | SOBETIROME |
|---|---|
| 中文同义词 | 化合物SOBETIROME;2-(4-(4-羟基-3-异丙基苄基)-3,5-二甲基苯氧基)乙酸 |
| 英文名称 | QRX 431 |
| 英文同义词 | Anti-solute carrier family 25 (mitochondrial carrier: glutamate), member 22;[4-(4-Hydroxy-3-isopropyl-benzyl)-3,5-dimethyl-phenoxy]-acetic acid;QRX 431;GC-1;SobetiroMe;[3,5-Dimethyl-4-(4-hydroxy-3-isopropylbenzyl)phenoxy]acetic acid;GC 1 (pharmaceutical);2-(4-(4-Hydroxy-3-isopropylbenzyl)-3,5-dimethylphenoxy)acetic acid |
| CAS号 | 211110-63-3 |
| 分子式 | C20H24O4 |
| 分子量 | 328.4 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 211110-63-3.mol |
| 结构式 |  |
SOBETIROME 性质
| 熔点 | 122 - 124°C |
|---|---|
| 沸点 | 510.2±45.0 °C(Predicted) |
| 密度 | 1.152±0.06 g/cm3(Predicted) |
| 储存条件 | -20°C |
| 溶解度 | DMSO：可溶10mg/mL，澄清 |
| 酸度系数(pKa) | 3.22±0.10(Predicted) |
| 形态 | 粉末 |
| 颜色 | 白色至米色 |
| InChIKey | QNAZTOHXCZPOSA-UHFFFAOYSA-N |
Sobetirome (GC-1) 是一种甲状腺激素受体 β (TRβ) 激动剂，Sobetirome可选择性结合到TRβ-1，EC50 为 0.16 μM。
EC50: 0.16 μM (TRβ-1), 0.58 μM (TRα-1)
Sobetirome (GC-1) is a thyroid hormone receptor β (TRβ)- and liver uptake-selective agonist. Sobetirome (48 nmol/kg) reduces high-density lipoprotein (HDL) cholesterol and very low-density lipoprotein (VLDL) triglyceride levels in euthyroid Mice. Sobetirome reduces HDL cholesterol and triglyceride Levels in hypercholesterolemic mice. Sobetirome increases hepatic HDL receptors and stimulates bile acid synthesis in hypercholesterolemic mice. Treatment with 10× Sobetirome (GC-1) results in a gain of fat mass of only 21% (1.7 g), and treatment with 20× Sobetirome (GC-1) induces a decrease in fat mass of 20% (1.3 g).
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-14823 | Sobetirome | 1 mg | 500元 | |
| 2024/01/25 | HY-14823 | SOBETIROME Sobetirome | 211110-63-3 | 5mg | 1100元 |