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| | 4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide, 97% Basic information |
| Product Name: | 4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide, 97% | | Synonyms: | 4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide, 97%;GSK137647A;GSK137647;4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide,97%;GSK137647A;GSK-137647A;GSK 137647A;GSK-137647;GSK 137647;GSK137647A, >98%;CS-2460;FFA4 (GPR120) agonist GS137647A | | CAS: | 349085-82-1 | | MF: | C16H19NO3S | | MW: | 305.39 | | EINECS: | | | Product Categories: | API | | Mol File: | 349085-82-1.mol |  |
| | 4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide, 97% Chemical Properties |
| Boiling point | 438.1±55.0 °C(Predicted) | | density | 1.214±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | Soluble to 100 mM in DMSO and to 50 mM in ethanol. | | form | powder | | pka | 9.23±0.10(Predicted) | | color | white to beige | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. | | CAS DataBase Reference | 349085-82-1 |
| | 4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide, 97% Usage And Synthesis |
| Description | GSK-137647 (349085-82-1) is a potent and selective agonist at free fatty acid receptor 4 (FFA4), also known as GPR120. pEC50s= 6.3, 6.2 and 6.1 for human, mouse and rat receptor respectively.1 GSK-137647 enhances glucose-stimulated insulin secretion in mouse insulinoma cells and induces intracellular calcium increase in U2OS osteosarcoma cells expressing GPR120.2 | | Uses | 4-Methoxy-N-(2,4,6-trimethylphenyl)benzenesulfonamide is involved in long-chain fatty acid stimulated GLP-1 secretion and has been implicated in glucose homeostasis, adiposity, and regulation of the anti-inflammatory response. It enhances glucose-stimulated insulin secretion in MIN6 cells. It induces intracellular calcium accumulation in U2OS cells; this activity is inhibited by AH 7614. | | in vitro | gsk137647a (50 μm) induced a concentration-dependent increase in glucose (25 mm)-stimulated insulin secretion in min6 mouse insulinoma cell line [1]. in addition, gsk137647a (100 μm) induced a modest increase in glp-1 secretion in the human intestinal cell line nci-h716. moreover, gsk137647a induced intracellular calcium accumulation in u2os cells [1]. | | in vivo | gsk137647a (50 μm) induced active glp-1 release by mouse circumvallate papillae (cvps) [2]. | | target | ffa4/gpr120 | | storage | Store at RT | | References | 1) Martin?et al. (2012),?Lipid-mediated release of GLP-1 by mouse taste buds from circumvallate papillae: putative involvement of GPR120 and impact on taste sensitivity; J. Lipid Res.,?53?2256
2) Sparks?et al. (2014),?Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120); Bioorg. Med. Chem. Lett.,?24?3100 |
| | 4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide, 97% Preparation Products And Raw materials |
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