阿塞那平盐酸盐
| 中文名称 | 阿塞那平盐酸盐 |
|---|---|
| 中文同义词 | 阿塞那平盐酸盐;化合物 T22589 |
| 英文名称 | Saphris hydrochloride |
| 英文同义词 | Asenapine (hydrochloride);Saphris hydrochloride;(3aS,12bS)-5-Chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole hydrochloride (1:1);Asenapine HCl;(3AS,12BS)-5-CHLORO-2-METHYL-2,3,3A,12B-TETRAHYDRO-1H-DIBENZO[2,3:6,7]OXEPINO[4,5-C]PYRROLE HYDROCHLORIDE;Asenapine HCl (Org 5222 HCl) |
| CAS号 | 1412458-61-7 |
| 分子式 | C17H17Cl2NO |
| 分子量 | 322.23 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 1412458-61-7.mol |
| 结构式 |  |
阿塞那平盐酸盐 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | DMSO：50 mg/mL（155.17 mM；需要超声波） |
| 形态 | 粉末 |
| 颜色 | 白色至米白色 |
|
sPLA2 2.5 nM (Ki) |
5-HT 2A Receptor 0.06 nM (Ki) |
5-HT 2C Receptor 0.03 nM (Ki) |
5-HT 7 Receptor 0.13 nM (Ki) |
D 2 Receptor 1.3 nM (Ki) |
D 3 Receptor 0.42 nM (Ki) |
D 4 Receptor 1.1 nM (Ki) |
Relative to its D2 receptor affinity, Asenapine has a higher affinity for 5-HT 2C , 5-HT 2A , 5-HT 2B , 5-HT 7 , 5-HT 6 , α 2B and D3 receptors, suggesting stronger engagement of these targets at therapeutic doses. Asenapine behaves as a potent antagonist (pK B ) at 5-HT 1A (7.4), 5-HT1B (8.1), 5-HT 2A (9.0), 5-HT 2B (9.3), 5-HT 2C (9.0), 5-HT 6 (8.0), 5-HT 7 (8.5), D2 (9.1), D3 (9.1), α 2A (7.3), α 2B (8.3), α 2C (6.8) and H1 (8.4) receptors.
Asenapine is an atypical antipsychotic that is currently available for the treatment of schizophrenia and bipolar I disorder. Asenapine may have superior therapeutic effect on anxiety symptoms than other agents in rats. Asenapine has anxiolytic-like effects in the EPM and the defensive marble burying tests in mice.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/08/19 | HY-16567 | Asenapine hydrochloride | 5 mg | 406元 | |
| 2024/08/19 | HY-16567 | 阿塞那平盐酸盐 Asenapine hydrochloride | 1412458-61-7 | 10mg | 650元 |