苦参新醇 A
| 中文名称 | 苦参新醇 A |
|---|---|
| 中文同义词 | 苦参醇A;苦参新醇 A;苦参新醇A对照品;苦参新醇A标准品;勒奇黄烷酮E;苦参醇A/苦参新醇A;苦参醇A,勒奇黄烷酮E |
| 英文名称 | Leachianone E |
| 英文同义词 | Kushenol A;Leachianone E;4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-(2-hydroxyphenyl)-8-[(2R)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]-, (2S)-;(2S)-5,7-dihydroxy-2-(2-hydroxyphenyl)-8-[(2R)-5-methyl-2-prop-1-en-2-ylhex-4-enyl]-2,3-dihydrochromen-4-one;4H-1-Benzopyran-4-one,2,3-dihydro-5,7-dihydroxy-2-(2-hydroxyphenyl)-8-[(2R)-5-methyl-2-(1-methylethenyl)-4-hexenyl]-, (2S)- |
| CAS号 | 99217-63-7 |
| 分子式 | C25H28O5 |
| 分子量 | 408.49 |
| EINECS号 | |
| 植物来源 | 苦参 |
| 相关类别 | 标准品;植物提取物;对照品;新品推荐;黄酮;标准品，对照品 |
| Mol文件 | 99217-63-7.mol |
| 结构式 |  |
苦参新醇 A 性质
| 熔点 | 175-178 °C |
|---|---|
| 沸点 | 581.7±50.0 °C(Predicted) |
| 密度 | 1.212±0.06 g/cm3(Predicted) |
| 储存条件 | 4°C, protect from light |
| 溶解度 | 溶于氯仿、二氯甲烷、乙酸乙酯、DMSO、丙酮等。 |
| 形态 | 水晶。 |
| 酸度系数(pKa) | 7.66±0.40(Predicted) |
Kushenol A (Leachianone E) 从苦参根中分离出来的。Kushenol A 是一种非竞争性酪氨酸酶 (tyrosinase) 抑制剂，可阻止 L-tyrosinase 转化为 L-DOPA，IC50 和 Ki 值分别为 1.1 μM 和 0.4 μM。Kushenol A 是一种类黄酮抗氧化剂，对 α-葡萄糖苷酶 (alpha-glucosidase) (IC50: 45 μM; Ki: 6.8 μM) 和 β-淀粉酶 (beta-amylase) 具有抑制作用。Kushenol A 被认为是化妆品针对皮肤美白和衰老的潜在酶抑制剂。
IC50: 1.1 μM (tyrosinase); 45 μM (alpha-glucosidase)
Kushenol A (25 μM) exhibits a highly potent inhibitory activity on ABTS+ radical scavenging with an IC 50 value of 9.7 ± 0.1 μM, and exhibits inhibits scavenging activity as a percentage 93.7% at 25 μM.Kushenol A (0-60 μg/ml; 24 hours) shows considerable cytotoxic effects against NSCLC cells, exhibits IC 50 values of 5.3 μg/ml and 20.5 μg/ml for A549 and NCI‐H226 cells, respectively. It shows an IC 50 value of 57.2 μg/ml for BEAS-2B cells.
Cell Viability Assay
| Cell Line: | NSCLC cell lines, A549 and NCI-H226Normal human lung epithelial: BEAS-2B |
| Concentration: | 0-60 μg/ml |
| Incubation Time: | 24 hours |
| Result: | Exhibited considerable cytotoxic effects against NSCLC cells. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-N2278 | Kushenol A | 1 mg | 3400元 | |
| 2024/01/25 | HY-N2278 | 苦参新醇 A Kushenol A | 99217-63-7 | 10 mM * 1 mLin DMSO | 7639元 |