CS-2649
| 中文名称 | CS-2649 |
|---|---|
| 中文同义词 | 7-氯-3-(P-甲苯基)-2H-苯并[B] [1,4]恶嗪;化合物AR7 |
| 英文名称 | AR7 |
| 英文同义词 | AR7;7-Chloro-3-(4-methylphenyl)-2H-1,4-benzoxazine;7-Chloro-3-p-tolyl-2H-benzo[b][1,4]oxazine;Atypical retinoid 7;Thyroid Hormone receptor,α1 human;c-ERBA-1;ERBA;ERB-T-1 |
| CAS号 | 80306-38-3 |
| 分子式 | C15H12ClNO |
| 分子量 | 257.71 |
| EINECS号 | |
| 相关类别 | 原料药及中间体 |
| Mol文件 | 80306-38-3.mol |
| 结构式 |  |
CS-2649 性质
| 储存条件 | Sealed in dry,2-8°C |
|---|---|
| 溶解度 | 在DMSO中的溶解度为20mg/mL，澄清 |
| 形态 | 粉末 |
| 颜色 | 白色至米色 |
| 稳定性 | 从购买之日起 2 年内保持稳定。 DMSO 溶液可在 -20°C 下保存长达 1 个月。 |
|
RARα
|
Treatment with RARA antagonist, AR7 (20 μM; for 16 h), increased lysosomal activity in WT and LRRK2
R1441G
KI mutant MEFs.
Chaperone-mediated autophagy (CMA) contributes to cellular quality control and the cellular response to stress through the selective degradation of cytosolic proteins in lysosomes. Decrease in CMA activity occurs in aging and in age-related disorders. Signaling through the retinoic acid receptor alpha (RARα) inhibits CMA. AR7, an RARα antagonist, significantly activates CMA activity in mouse fibroblasts. A marked increase in CMA-activating potency is found when AR7 and GR1 are combined, supporting their cooperative effect. Treatment with the transcriptional repressor Actinomycin D partially reduces the stimulatory effect of AR7 on CMA, consistent with transcriptional changes contributing to the upregulation of CMA.
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-101106 | AR7 | 1 mg | 272元 | |
| 2024/01/25 | HY-101106 | CS-2649 AR7 | 80306-38-3 | 5mg | 600元 |