7ACC-2

7ACC-2

中文名称7ACC-2
中文同义词7-[苄基(甲基)氨基]-2-氧代-2H-苯并吡喃-3-羧酸;MCT抑制剂(7ACC2)
英文名称7ACC-2
英文同义词7ACC 2;7ACC2;7ACC-2;7-[Benzyl(methyl)amino]-2-oxo-2H-chromene-3-carboxylic acid;7ACC 2; 7ACC-2; 7ACC 2; 7ACC-2;7-[benzyl(methyl)amino]-2-oxochromene-3-carboxylic acid;2H-1-Benzopyran-3-carboxylic acid, 7-[methyl(phenylmethyl)amino]-2-oxo-;7ACC2,MPC,MCT1,7ACC-2,Monocarboxylate Transporter,Inhibitor,lactate,pyruvate,Mitochondrial Metabolism,radiosensitizes,antitumor,mitochondrial,inhibit
CAS号1472624-85-3
分子式C18H15NO4
分子量309.32
EINECS号604-604-1
相关类别小分子抑制剂,天然产物;小分子抑制剂;细胞生物学试剂;医药;Inhibitors
Mol文件1472624-85-3.mol
结构式7ACC-2 结构式

7ACC-2 性质

沸点548.9±50.0 °C(Predicted)
密度1.368±0.06 g/cm3(Predicted)
储存条件2-8°C
溶解度不溶于乙醇;不溶于水; DMSO 中≥47.5 mg/mL
形态粉末
酸度系数(pKa)-98.37±0.20(Predicted)

7ACC-2 用途与合成方法

7ACC2是一种有效的MCT1抑制剂,在SiHa人源宫颈细胞癌中抑制乳酸吸收,IC50为10 nM。
TargetValue
MCT1
()

7ACC2 (compound 19; 72 hours) inhibits SiHa cells proliferation in lactate-containing medium with an EC50 of 0.22 μM. In SiHa cells, lactate uptake primarily depends on the high affinity MCT1 transporter.
7ACC2 (compound 19) shows an excellent chemical stability in simulated gastric (SGF) and intestinal (SIF) fluids, a good apparent permeability coefficient (Papp) through Caco-2 monolayer and a high metabolic stability on mouse (MLM) and human liver microsomes (HLM) as well as on human hepatocytes.
7ACC2 is a potent inhibitor of mitochondrial pyruvate transport which consecutively blocks extracellular lactate uptake by promoting intracellular pyruvate accumulation.

7ACC2 (3 mg/kg; intraperitoneal administration; daily; for 5 days or 10days) treatment significantly inhibits tumor growth in mice. 7ACC2 radiosensitizes tumor cells by reducing hypoxia in vivo.
The intraperitoneal administration of 7ACC2 (compound 19; 3 mg/kg) to mice leads to a C max of 1246 ng/ml (4 μM) in a very short time (T max =10 min) associated with a plasma half-life of 4.5 h.

Animal Model: 7-week-old female NMRI nude mice with radiotherapy administered
Dosage: 3 mg/kg
Administration: Intraperitoneal administration; daily; for 5 days or 10days
Result: A significant increase in tumor growth delay was observed.

安全信息

海关编码2932990090

MSDS信息

更新日期产品编号产品名称CAS号包装价格
2024/01/25HY-D07137ACC-2
7ACC2
1472624-85-32mg600元
2024/01/25HY-D07137ACC-2
7ACC2
1472624-85-35mg900元

7ACC-2 上下游产品信息

"7ACC-2"相关产品信息
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