Dicyclomine hydrochloride 是一种有效的口服活性毒蕈碱胆碱能受体 (muscarinic cholinergic receptors) 拮抗剂。Dicyclomine hydrochloride 对 M1 受体亚型 (Ki=5.1 nM) 和 M2 受体亚型 (Ki=54.6 nM) 在刷缘膜和基底质膜中均表现出较高的亲和力。Dicyclomine hydrochloride是一种抗痉挛试剂,在体内可缓解胃肠道平滑肌痉挛。
Ki: 5.1 nM (muscarinic M1 receptor subtype in brush-border membrane)Ki: 54.6 nM (muscarinic M2 receptor subtype in basal plasma membrane
Dicyclomine hydrochloride (intraperitoneal injection; 8 mg/kg; daily) exacerbates the cognitive impairments in all the measurements. In addition, the memory impairments are worse in dicyclomine-treated 3xTg-AD mice compared to dicyclomine-treated NonTg mice.Dicyclomine hydrochloride (intraperitoneal injection; 2.0, 4.0, and 8.0 mg/kg; 7 days) produces a highly significant effect on performance in the paired-associates learning (PAL) task in mice.And systemic treatment at lower doses show behavioral impairments in mice in spatial tasks.
Animal Model:
|
C57Bl/6 mice
|
Dosage:
|
2.0, 4.0, and 8.0 mg/kg
|
Administration:
|
Intraperitoneal injection; daily; 7 days
|
Result:
|
Produced impairments due to actions of the agent outside of the hippocampus.
|
类别
有毒物品
毒性分级
中毒
急性毒性
口服-大鼠 LD50: 625 毫克/公斤; 口服-小鼠 LD50: 625 毫克/公斤
可燃性危险特性
可燃;燃烧产生有毒氮氧化物和氯化氢烟雾;病人用药副作用;僵硬,呼吸困难,苍白
储运特性
通风低温干燥
灭火剂
干粉,泡沫,沙土,二氧化碳, 雾状水