RO 15-4513
| 中文名称 | RO 15-4513 |
|---|---|
| 中文同义词 | 化合物 T16775;化合物 RO15-4513 |
| 英文名称 | Ro 15-4513 |
| 英文同义词 | 8-AZIDO-5,6-DIHYDRO-5-METHYL-6-OXO-4H-IMIDAZO[1,5-A][1,4]BENZODIAZEPINE-3-CARBOXYLIC ACID ETHYL ESTER;ETHYL 8-AZIDO-6-DIHYDRO-5-METHYL-6-OXO-4H-IMIDAZO[1,5-A]-[1,4]BENZODIAZEPINE-3-CARBOXYLATE;4H-Imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid, 8-azido-5,6-dihydro-6-oxo-, ethyl ester;8-Azido-5,6-dihydro-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid ethyl ester;Azidomazenil;Ethyl 8-azido-6-dihyro-5-methyl-6-oxo-4H-imidazo[1,5-A][1,4]benzodiazepine-3-carboxylic acid ethyl ester;4H-Imidazo(1,5-A)(1,4)benzodiazepine-3-carboxylic acid, 8-azido-5,6-dihydro-5-methyl-6-oxo-, ethyl ester;Ethyl-8-azido-5,6-dihydro-5-methyl-6-oxo-4H-imidazo-1,4-benzodiazepine-3-carboxylate |
| CAS号 | 91917-65-6 |
| 分子式 | C15H14N6O3 |
| 分子量 | 326.32 |
| EINECS号 | |
| 相关类别 | GABA/Glycine receptor |
| Mol文件 | 91917-65-6.mol |
| 结构式 |  |
RO 15-4513 性质
| 储存条件 | Desiccate at +4°C |
|---|---|
| 溶解度 | 45%(w/v)aq2-羟丙基-β-环糊精：0.8 mg/mL |
| 形态 | 固体 |
| 颜色 | 棕褐色 |
| 水溶解性 | 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.8mg/mL H2O: insoluble methanol: soluble |
| InChI | 1S/C15H14N6O3/c1-3-24-15(23)13-12-7-20(2)14(22)10-6-9(18-19-16)4-5-11(10)21(12)8-17-13/h4-6,8H,3,7H2,1-2H3 |
| InChIKey | CFSOJZTUTOQNIA-UHFFFAOYSA-N |
| SMILES | CCOC(=O)c1ncn-2c1CN(C)C(=O)c3cc(ccc-23)N=[N+]=[N-] |
| CAS 数据库 | 91917-65-6 |
Ro15-4513 是咪唑并苯二氮酮衍生物，是苯二氮卓受体 (BZR) 的部分反向激动剂。Ro15-4513 是有效的乙醇 (ethanol) 拮抗剂。Ro15-4513 具有抗焦虑作用。
BZR; ethanol;
Ro15-4513 usually acts as a partial inverse agonist at GABA A receptors, except an agonist for α4 and α6 subunit-containing ones.
Ro 15-4513 (i.p.; 3 mg/kg; 10 min before being tested) completely inhibits the ethanol-induced (1.8 g/kg) reduction in total locomotor activity and partly the reduction in rearing.
Ro 15-4513 (i.p.; 3 mg/kg; 15 min before administration of 1.5 g/kg ethanol) reverses ethanol-induced sedation in GABA
A
receptor δ subunit-deficient mice.
| Animal Model: | Male C57BL/6J mice |
| Dosage: | 3 mg/kg |
| Administration: | I.p.; 10 min before being tested |
| Result: | Completely inhibited the ethanol-induced reduction in total locomotor activity and partly the reduction in rearing. |
安全信息
| WGK Germany | 3 |
|---|---|
| 存储类别 | 11 - 可燃固体 |
| 提供商 | 语言 |
|---|---|
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英文
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| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/09/15 | HY-103476 | RO 15-4513 Ro15-4513 | 91917-65-6 | 1mg | 710元 |
| 2026/09/15 | HY-103476 | RO 15-4513 Ro15-4513 | 91917-65-6 | 5mg | 1350元 |