ML329
| 中文名称 | ML329 |
|---|---|
| 中文同义词 | 4-((1,4-二氧代-1,4-二氢萘-2-基)氨基)苯磺酰胺;化合物ML329 |
| 英文名称 | ML329 |
| 英文同义词 | ML329;Benzenesulfonamide, 4-[(1,4-dihydro-1,4-dioxo-2-naphthalenyl)amino]-;4-((1,4-Dioxo-1,4-dihydronaphthalen-2-yl)amino)benzenesulfonamide;ML329;ML 329;ML-329,ML329,ML 329,Inhibitor,inhibit |
| CAS号 | 19992-50-8 |
| 分子式 | C16H12N2O4S |
| 分子量 | 328.34 |
| EINECS号 | 604-604-1 |
| 相关类别 | |
| Mol文件 | 19992-50-8.mol |
| 结构式 |  |
ML329 性质
| 储存条件 | 2-8°C(protect from light) |
|---|---|
| 溶解度 | DMF：20mg/mL； DMSO：20mg/mL； DMSO:PBS (pH 7.2) (1:1)：0.5 mg/ml；乙醇：0.1mg/mL |
| 形态 | 结晶固体 |
| Target | Value |
|
MITF
() | |
|
TRPM-1 promoter
(Cell-free assay) | 1.2 μM |
ML329 inhibits the expression of numerous micropthalmia-associated transcription factor (MITF) target genes and blocks the proliferation of numerous cell lines that require MITF for proliferation. ML329 could directly or indirectly interact with MITF or components of the MITF regulatory network. As a transcription factor that regulates cell cycle and pigmentation, interference of MITF with ML329 will be useful in characterizing the specific roles of MITF in melanoma and validate blockade of MITF function as a potential treatment of melanoma. ML329 shows specific activity against the MITF-dependent cells, primary melanocytes but no effect on the viability in A375 cells. ML329 reduces the expression of multiple MITF target genes, including pigment-related genes and the cell cycle regulator CDK2. As a tool compound, ML329 will be useful in elucidating the role of MITF in melanocyte lineage development and in melanoma disease progression.
安全信息
| 海关编码 | 2935909099 |
|---|
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-101464 | ML329 | 1 mg | 613元 | |
| 2024/01/25 | HY-101464 | ML329 ML329 | 19992-50-8 | 5mg | 1350元 |