1435786-04-1
中文名称 | 1435786-04-1 |
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中文同义词 | 化合物RAPASTINEL TRIFLUOROACETATE |
英文名称 | GLYX13 |
英文同义词 | Rapastinel Trifluoroacetate;GLYX 13,inhibit,Rapastinel Trifluoroacetate,GLYX13,GLYX-13,Inhibitor,Rapastinel,Ionotropic glutamate receptors,iGluR |
CAS号 | 1435786-04-1 |
分子式 | C20H32F3N5O8 |
分子量 | 527.5 |
EINECS号 | |
相关类别 | |
Mol文件 | 1435786-04-1.mol |
结构式 |
1435786-04-1 性质
储存条件 | Store at -20°C |
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溶解度 | 二甲基亚砜:125 mg/mL(236.97 mM) |
NMDA receptor
Rapastinel Trifluoroacetate is an NMDA receptor modulator with glycine-site partial agonist properties and currently in a phase II clinical development program as an adjunctive therapy for major depressive disorder. Mice given Rapastinel Trifluoroacetate (1.0 mg/kg) prior to acute ketamine (30 mg/kg) show clear preference for novel compare to familiar objects (P<0.01). Rapastinel Trifluoroacetate produces an antidepressant like effect in the USVs test, as indexed by an increase in hedonic 50-kHz USVs [F(1,20)=12.4, P<0.05] and a decrease in aversive 20-kHz USVs [F(1,20)=6.8, P<0.05]. Rapastinel Trifluoroacetate also produces an anxiolytic effect in the open field, as indexed by increased center time [F(1,20)=19.2, P<0.05] without altering locomotor activity as measured by line crosses [F(1,20)=0.0, P>0.05].
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/01/25 | HY-16728B | 1435786-04-1 Rapastinel Trifluoroacetate | 1435786-04-1 | 1mg | 990元 |
2024/01/25 | HY-16728B | 1435786-04-1 Rapastinel Trifluoroacetate | 1435786-04-1 | 5mg | 3100元 |