COMPOUND 3K

COMPOUND 3K

中文名称COMPOUND 3K
中文同义词PKM2抑制剂(化合物3K);PKM2抑制剂(PKM2-IN-1);化合物PKM2 INHIBITOR;(3-甲基-1,4-二氧代-1,4-二氢萘-2-基)甲基 哌啶-1-二硫代甲酸酯
英文名称PKM2 inhibitor
英文同义词PKM2 inhibitor;PKM2-IN-1;compound 3k;PKM2 inhibitor(compound 3k);PKM2-IN-1;COMPOUND 3K;piperidine-1-carbodithioic acid 3-methyl-1,4-dioxo-1,4-dihydronaphthalen-2-ylmethyl ester;PKM2 inhibitor 1;1-Piperidinecarbodithioic acid, (1,4-dihydro-3-methyl-1,4-dioxo-2-naphthalenyl)methyl ester
CAS号94164-88-2
分子式C18H19NO2S2
分子量345.48
EINECS号
相关类别细胞生物学试剂
Mol文件94164-88-2.mol
结构式COMPOUND 3K 结构式

COMPOUND 3K 性质

沸点496.5±55.0 °C(Predicted)
密度1.302±0.06 g/cm3(Predicted)
储存条件Sealed in dry,Store in freezer, under -20°C
溶解度DMF:1mg/mL; DMSO: 不溶;乙醇:insol; PBS (pH 7.2):不溶
形态固体
酸度系数(pKa)0.81±0.20(Predicted)
颜色浅黄至黄色

COMPOUND 3K 用途与合成方法

PKM2-IN-1 是一种丙酮酸激酶 M2 (PKM2) 抑制剂,其 IC50 值为 2.95 μM。

IC50: 2.95 μM (PKM2)

PKM2-IN-1 is a pyruvate kinase M2 (PKM2) inhibitor with an IC 50 of 2.95±0.53 μM. Results show that most of the tested compounds exhibit some degree of PKM2 inhibition and some compounds, such as PKM2-IN-1 (compound 3k) and 6d, display more potent activity than the positive control shikonin. The representative compounds PKM2-IN-1, 6d display dose-dependent inhibition of PKM2 with less inhibition of PKM1 and PKL like shikonin. Among all tested compounds, the most potent compounds are 3a, PKM2-IN-1 and 3r, which exhibit IC 50 values against HCT116 and Hela cells ranging from 0.39 to 0.41 μM, 0.18 to 0.29 μM and 0.18 to 0.38 μM, respectively.

安全信息

MSDS信息

更新日期产品编号产品名称CAS号包装价格
2024/08/19HY-103617PKM2-IN-11 mg320元
2024/08/19HY-103617COMPOUND 3K
PKM2-IN-1
94164-88-25mg800元

COMPOUND 3K 上下游产品信息

"COMPOUND 3K"相关产品信息
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