ML204 HYDROCHLORIDE
| 中文名称 | ML204 HYDROCHLORIDE |
|---|---|
| 中文同义词 | 4-甲基-2-(哌啶-1-基)喹啉盐酸盐;化合物 T24481 |
| 英文名称 | ML 204 |
| 英文同义词 | ML204 hydrochloride,ML-204 hydrochloride |
| CAS号 | 2070015-10-8 |
| 分子式 | C15H19ClN2 |
| 分子量 | 262.78 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 2070015-10-8.mol |
| 结构式 |  |
ML204 HYDROCHLORIDE 性质
| 储存条件 | under inert gas (nitrogen or Argon) at 2-8°C |
|---|
|
TRPC4
|
TRPC5
|
ML204 hydrochloride inhibits TRPC4β-mediated intracellular Ca
2+
rise with an IC
50
value of 0.96 μM (HEK293 cells) and exhibits 19-fold selectivity against muscarinic receptor-coupled TRPC6 channel activation.
ML204 hydrochloride blocks TRPC4β activity induced through either G
i/o
stimulation by μ-opioid, 5HT
1A
serotonin, and M
2
muscarinic receptors or G
q/11
stimulation by the endogenous M
3
-like muscarinic receptors.
ML204 hydrochloride blocks LPS-induced TRPC5 channel activity.
ML204 hydrochloride (1 mg/kg; s.c.; twice a day; for 5 days) causes mortality associated with exacerbated hypothermia and decreases peritoneal leukocyte numbers and cytokines in LPS-injected mice.
| Animal Model: | Nonfasted male C57BL/6 (2-3 months) |
| Dosage: | 1 mg/kg |
| Administration: | Subcutaneous injection, twice a day, for 5 days (prior to LPS injection) |
| Result: | Induces mortality associated with increased hypothermia in mice with LPS-induced systemic inflammatory response. |