929895-45-4
| 中文名称 | 929895-45-4 |
|---|---|
| 中文同义词 | 解旋酶FANCJ和DING抑制剂;化合物 T13817L |
| 英文名称 | Phen-DC3 Trifluoromethanesulfonate |
| 英文同义词 | Phen-DC3 Triflate;Phen-DC3 Trifluoromethanesulfonate |
| CAS号 | 929895-45-4 |
| 分子式 | C36H26F6N6O8S2 |
| 分子量 | 848.7474592 |
| EINECS号 | |
| 相关类别 | 细胞生物学试剂 |
| Mol文件 | 929895-45-4.mol |
| 结构式 |  |
929895-45-4 性质
| 熔点 | >260 °C(Solv: ethyl ether (60-29-7)) |
|---|---|
| 储存条件 | Store at -20°C |
| 溶解度 | 二甲基亚砜：≥34 mg/ml（40.06mM） |
Phen-DC3 Trifluoromethanesulfonate 是一个 G4 特异性配体，可以抑制解旋酶 FANCJ 和 DinG 且 IC50s 值分别为 65±6 和 50±10 nM。
IC50: 65±6 nM (G4 substrate, FANCJ helicase), 50±10 nM (G4 substrate, DinG helicases)
In WT cells, a CEB1-WT array is rather stable but undergoes frequent rearrangements upon addition of 10 μM Phen-DC3 Trifluoromethanesulfonate (Phen-DC3). It is found that the c-Myc allele exhibits significant destabilization upon Phen-DC3 Trifluoromethanesulfonate treatment and PIF1 deletion. The CEB25-L111(T) array is stable in WT cells, it becomes unstable upon addition of Phen-DC3 Trifluoromethanesulfonate or deletion of PIF1. It is also highly destabilized in the presence of Phen-DC3 Trifluoromethanesulfonate or in the absence of PIF1. The CEB1-loop CEB25 allele remaines fully stable in both PIF1-treated and WT cells.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-15594A | 929895-45-4 Phen-DC3 Trifluoromethanesulfonate | 929895-45-4 | 1mg | 600元 |
| 2024/01/25 | HY-15594A | 929895-45-4 Phen-DC3 Trifluoromethanesulfonate | 929895-45-4 | 5mg | 1035元 |