支脱皂苷元
| 中文名称 | 支脱皂苷元 |
|---|---|
| 中文同义词 | 支脱皂苷元;支脱皂苷元(吉托皂苷元);芰脱皂苷元;吉托皂苷元;芰脱皂甙元;吉托皂苷元(标准品);吉托皂苷元(芰脱皂甙元);皂甙元 |
| 英文名称 | (25R)-5ALPHA-SPIROSTAN-2ALPHA,3BETA-DIOL |
| 英文同义词 | GITOGENIN;DIGIN;(25R)-2α,3β-Dihydroxy-5α-spirostan;(25R)-2α,3β-Dihydroxy-5α-spirostane;(2alpha,3beta,5alpha,25R)-Spirostan-2,3-diol;2alpha-Hydroxytigogenin;(25R)-5ALPHA-SPIROSTAN-2ALPHA,3BETA-DIOL;NSC 147752 |
| CAS号 | 511-96-6 |
| 分子式 | C27H44O4 |
| 分子量 | 432.64 |
| EINECS号 | |
| 相关类别 | 中药对照品;对照品、标准品，植物单体，植物提取物;标准品;对照品;植提标准品;植物提取物;对照品-中药对照品;标准品 -中药标准品;标准品，对照品 |
| Mol文件 | 511-96-6.mol |
| 结构式 |  |
支脱皂苷元 性质
| 熔点 | 272-273℃ |
|---|---|
| 比旋光度 | D20 -75° (c = 1.02 in CHCl3) |
| 沸点 | 466.26°C (rough estimate) |
| 密度 | 1.16 |
| 折射率 | 1.4840 (estimate) |
| 溶解度 | 氯仿：30mg/mL |
| 形态 | 固体 |
| 酸度系数(pKa) | 14.62±0.70(Predicted) |
IC50: 0.69 µM (UDP-glucuronosyltransferase 1A4); IC50: 37.2 μM (α-glucosidase)
When tamoxifen is used as the substrate metabolized by UGT1A4 in HLMs, Gitogenin exhibits potent inhibition of tamoxifen, with an IC 50 value of 6.13 µM. Similarly, for midazolam as the substrate of UGT1A4, the IC 50 value is 5.7 µM. In addition, when olanzapine is used as a substrate of UGT1A4, the IC 50 value is determined as 6.0 µM. Finally, we also evaluats Gitogenin for asenapine glucuronidation mediated by UGT1A4, and similar inhibition effect is observed, with an IC 50 value of 22.0 µM.
Stimulation of growth hormone release is investigated on rat pituitary cells in vitro. Gitogenin (20 μg/mL) shows rat growth-hormone (rGH) release stimulating activities (26.1 ng/mL).
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-N2574 | Gitogenin | 1 mg | 902元 | |
| 2024/01/25 | HY-N2574 | 支脱皂苷元 Gitogenin | 511-96-6 | 5mg | 2370元 |