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| | 1-ヒドロキシベンゾトリアゾール一水和物 製品概要 |
| | 1-ヒドロキシベンゾトリアゾール一水和物 物理性質 |
| 主な危険性 | F,Xi,T,E | | Rフレーズ | 11-5-36/38-36/37/38-36-20/21-61-2 | | Sフレーズ | 16-33-7/9-26-45-53-15-36/37-35 | | RIDADR | 1325 | | RTECS 番号 | DM1288000 | | 国連危険物分類 | 4.1 | | 容器等級 | III | | HSコード | 29339980 | | 毒性 | rat,LDLo,oral,5gm/kg (5000mg/kg),Acute Toxicity Data. Journal of the American College of Toxicology, Part B. Vol. 1, Pg. 679, 1992. |
| | 1-ヒドロキシベンゾトリアゾール一水和物 Usage And Synthesis |
| 溶解性 | 1g/100ml(エチルアルコール), DMF, DMSO, ピリジン, THF, メタノール, エタノールによく溶け、水, ジオキサン, クロロホルム, アセトンにわずかに溶ける。塩化メチレン, 酢酸エチル, ベンゼン, エーテル, ヘキサンには溶けない。 | | 用途 | 1-ヒドロキシベンゾトリアゾール（1-hydroxybenzotriazole）は、有機合成においてアミド結合生成反応に常用される試薬の一つ。
| | 化学的特性 | white to light yellow powder | | 使用 | additive for oligonucleotide couplings and in racemization-free peptide couplings | | 使用 | 1-Hydroxybenzotriazole (HOBT) is used in preparation method of carbon fiber/polyamide composite powder material for laser sintering. | | 定義 | ChEBI: 1-Hydroxybenzotriazole is a member of benzotriazoles. | | 燃焼性と爆発性 | Not classified | | 生物活性 | hydroxy benzotriazole, abbreviated hobt, is anorganic compoundthat is a derivative of benzotriazole. hobt, as a commercial product, is a white crystalline powder contains some water (~11.7% wt as the hobt monohydrate crystal). it is mainly used to suppress the racemization of single-enantiomerchiral molecules and to improve the efficiency ofpeptide synthesis. automated peptide synthesisinvolves the condensation of the amino group of protected amino acidswith the activated ester. hobt can be used to produce activated esters such as n-hydroxysuccinimide ester. these esters are insoluble and react with amines at ambient temperature to give amides [1]. hobt is also used for the synthesis of amides from carboxylic acidsaside from amino acids. these substrates may not be convertible to theacyl chlorides [2]. for instance amide derivatives of ionophoric antibiotics have been prepared in this way [3]. | | target | racemization | | 純化方法 | Crystallise HOBt from aqueous EtOH or water. [Boyle & Jones J Chem Soc Perkin Trans II 160 1973, Tomita & Ikawa J Pharm Soc Jpn 75 449 1955, Beilstein 26 III/IV 95.] | | 参考文献 | [1]. knig w, geiger r. eineneuemethodezursynthese von peptiden: aktivierung der carboxylgruppemitdicyclohexylcarbodiimidunterzusatz von 1‐hydroxy‐benzotriazolen[j]. chemischeberichte, 1970, 103(3): 788-798.
[2]. myers a g, yang b h, chen h. transformation of pseudoephedrine amides into highly enantiomerically enriched aldehydes, alcohols, and ketones[j]. organic syntheses, 2000: 29-29.
[3]. owicki d, huczyński a, ratajczak-sitarz m, et al. structural and antimicrobial studies of a new n-phenylamide of monensin a complex with sodium chloride[j]. journal of molecular structure, 2009, 923(1): 53-59. |
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