酮咯酸氨丁三醇
| 中文名称 | 酮咯酸氨丁三醇 |
|---|---|
| 中文同义词 | (+/-)-5-苯甲酰基-2,3-二氢-1H-吡咯里嗪-1-甲酸氨丁三醇盐;辛太克斯(浮选剂);酮咯酸氨丁三醇;酮咯酸氨丁三醇/(+/-)-5-苯甲酰基-2,3-二氢-1H-吡咯里嗪-1-甲酸氨丁三醇盐;安贺拉PF;酮咯酸三醇;酮咯酸氨三丁醇;酮咯酸氨丁三醇(标准品) |
| 英文名称 | Ketorolac tromethamine |
| 英文同义词 | KETOROLAC TRIS SALT;KETOROLAC TROMETHAMINE;(+/-)-5-BENZOYL-2,3-DIHYDRO-1H-PYRROLIZINE-1-CARBOXYLIC ACID, TRIS (HYDROXYMETHYL) AMINOMETHANE SALT;(+/-)-5-benzoyl-2,3-dihydro-1h-pyrrolizine-1-carboxylic acid tris(hydroxymethyl)methylamine salt;(+/-)-5-BENZOYL-2,3-DIHYDRO-1H-PYRROLIZINE-1-CARBOXYLIC ACID TRIS SALT;KETROLAC TROMETHAMINE SALT;(±)-Form tromethamine salt;KEROROLACTROMETHAMINE |
| CAS号 | 74103-07-4 |
| 分子式 | C19H24N2O6 |
| 分子量 | 376.41 |
| EINECS号 | |
| 相关类别 | 神经信号;医药中间体;小分子抑制剂;水电平衡及透析用药物;医药与生物化工;原料药;医药原料;中间体;化合物：原料药;医药产品;眼科类药物;Aromatics;Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Pharmaceutical raw material;API;Acular;Other APIs;11;醇类;医药原料药;医药、农药及染料中间体;化工原料;杂质对照品;化学试剂;对照品-杂质对照品;试剂 |
| Mol文件 | 74103-07-4.mol |
| 结构式 |  |
酮咯酸氨丁三醇 性质
| 熔点 | 160-161 C |
|---|---|
| 储存条件 | 2-8°C |
| 溶解度 | H2O: 15 mg/mL ，−20 °C 下至少稳定一个月，可溶 |
| 形态 | 结晶 |
| 颜色 | 白色至浅黄色至浅橙色 |
| 生物来源 | synthetic (organic) |
| 水溶解性 | H2O: soluble 15mg/mL, clear, colorless to faintly yellow (stable at least one month at -20 °C.) |
| 最大波长(λmax) | 322nm(MeOH)(lit.) |
| Merck | 14,5306 |
| 稳定性 | 吸湿性 |
| InChI | InChI=1S/C15H13NO3.C4H11NO3/c17-14(10-4-2-1-3-5-10)13-7-6-12-11(15(18)19)8-9-16(12)13;5-4(1-6,2-7)3-8/h1-7,11H,8-9H2,(H,18,19);6-8H,1-3,5H2 |
| InChIKey | BWHLPLXXIDYSNW-UHFFFAOYSA-N |
| SMILES | C(N)(CO)(CO)CO.C(C1C=CC=CC=1)(C1=CC=C2C(C(=O)O)CCN12)=O |
| CAS 数据库 | 74103-07-4(CAS DataBase Reference) |
| Target | Value |
|
COX1
() | 20 nM |
|
COX2
() | 20 nM |
Ketorolac is a non-steroidal anti-inflammatory agent, acting as a nonselective COX inhibitor, with IC 50 s of 20 nM for COX-1 and 120 nM for COX-2.
Ketorolac tromethamine (0.4%) causes nearly complete inhibition on LPS endotoxin-induced increases in FITC-dextran in the anterior chamber, and increases in aqueous PGE2 concentrations in the aqueous humor in rabbits. Ketorolac (30 mg/kg, i.v.) rapidly reverses hyperalgesia in rats. Ketorolac also reduces carrageenan-induced hyperalgesia and paw PG production, and causes reduction in PGE2 levels in rats. Ketorolac (4 mg/kg/day, p.o.) has no detrimental effect in the volume fraction of bone trabeculae formed inside the alveolar socket in rats. Ketorolac (60 μg/10 μL) reduces the histological changes such as ischemic cell death, including cytoplasmic eosinophilia with disintegration of cytoarchitecture and nuclear pyknosis in rats. Ketorolac also effectively reduces neuronal death and improves hindlimb motor function, and the long-term survival is similar to that in the control group.
安全信息
| 危险品标志 | T |
|---|---|
| 危险类别码 | 25-36/37/38-23/24/25 |
| 安全说明 | 26-45-36/37/39 |
| 危险品运输编号 | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS号 | UY7759900 |
| 危险等级 | 6.1(a) |
| 包装类别 | II |
| 海关编码 | 2933995500 |
| 提供商 | 语言 |
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英文
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| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025/02/08 | HY-B0138 | 酮咯酸氨丁三醇 Ketorolac tromethamine salt | 74103-07-4 | 25 mg | 148元 |
| 2025/02/08 | HY-B0138 | 酮咯酸氨丁三醇 Ketorolac tromethamine salt | 74103-07-4 | 10mM * 1mLin DMSO | 162元 |