化合物FTBMT
| 中文名称 | 化合物FTBMT |
|---|---|
| 中文同义词 | 化合物FTBMT |
| 英文名称 | FTBMT |
| 英文同义词 | FTBMT;Benzamide, 4-[3-[[3-fluoro-5-(trifluoromethyl)phenyl]methyl]-5-methyl-1H-1,2,4-triazol-1-yl]-2-methyl-;FTBMT >=98% (HPLC);4-(3-{[3-fluoro-5-(trifluoromethyl)phenyl]methyl}-5 -methyl-1H-1,2,4-triazol-1-yl)-2-methylbenzamide;inhibit,FTBMT,Inhibitor;TP-024 |
| CAS号 | 1358575-02-6 |
| 分子式 | C19H16F4N4O |
| 分子量 | 392.35 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 1358575-02-6.mol |
| 结构式 |  |
化合物FTBMT 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | DMSO：69.62（最大浓度 mg/mL）；177.44（最大浓度 mM） |
FTBMT 是选择性的 GPR52 激动剂， EC50 为 75 nM。FTBMT 有抗精神病和促进认知活性。
IC50: 75 nM (GPR52)
FTBMT (0.1-10 μM) increases intracellular cAMP levels in CHO cells expressing human, mouse, or rat GPR52, with pEC 50 s of 7.03, 6.85, and 6.87, respectively.
Cell Viability Assay
| Cell Line: | CHO cells (expressing GPR52 receptors) cAMP assay |
| Concentration: | 0.1-10 μM |
| Incubation Time: | 30 minutes |
| Result: | FTBMT activated cAMP signaling in vitro [1] . |
FTBMT (30 mg/kg, 90 minutes) exhibits antipsychotic-like activity without causing catalepsy in mice.
FTBMT (3 or 10 mg/kg, 48 hours) improves recognition and spatial working memory in rats.
FTBMT (3, 10, 30 mg/kg, 2 hours) stimulates neuronal activity in brain regions related to cognition.
| Animal Model: | Male Long-Evans rats (9 weeks old) |
| Dosage: | 10 mg/kg |
| Administration: | Oral, 1 hour before memory test |
| Result: | A 1-hour pretreatment with FTBMT (10 mg/kg, p.o.) significantly decreases the number of memory errors induced by MK-801 [2] . |
| Animal Model: | Male ICR mice (7 to 8 weeks old) |
| Dosage: | 3–30 mg/kg |
| Administration: | Oral, 60 minutes before s.c. administration of MK-801 |
| Result: | FTBMT increases phospho-DARPP32 levels in the NAc slices [2] . |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-101787 | 化合物FTBMT FTBMT | 1358575-02-6 | 5mg | 1100元 |
| 2024/01/25 | HY-101787 | 化合物FTBMT FTBMT | 1358575-02-6 | 10 mM * 1 mLin DMSO | 1210元 |