MDL 19301
中文名称 | MDL 19301 |
---|---|
中文同义词 | 化合物 T11981 |
英文名称 | MDL 19301 |
英文同义词 | MDL 19301;Benzenamine, N-1,3-dithiolan-2-ylidene-4-hexyl- |
CAS号 | 89388-38-5 |
分子式 | C15H21NS2 |
分子量 | 279.46 |
EINECS号 | |
相关类别 | |
Mol文件 | 89388-38-5.mol |
结构式 |
MDL 19301 性质
储存条件 | Store at -20°C |
---|---|
溶解度 | 溶于二甲基亚砜 |
Oral administration of MDL 19301 inhibits rat paw edema induced by carrageenan (ED 30 =4.8 mg/kg) or an Arthus reaction (ED 30 =8.2 mg/kg p.o.). The oral dose which induces gastric ulceration in 50% of fasted rats is greater than 1,000 mg/kg, demonstrating a more favorable therapeutic ratio than conventional nonsteroidal anti‐inflammatory agents. The anti-inflammatory activity of MDL 19301, but not that of MDL 16,861, is attenuated by co-administration of an inhibitor of drug metabolite (SKF525A). This suggests that MDL 19301 is a prodrug of MDL 16,861 and this phenomenon would explain its lack of ulcerogenicity. Additional anti-inflammatory properties of MDL 19301 include inhibition of carrageenan pleurisy, adjuvant arthritis, and HOAc-induced writhing. Other pharmacological data indicate that MDL 19301 administration results in inhibition of prostaglandin synthesis; inhibition of arachidonic acid-induced, but not prostaglandin-E2-induced, diarrhea in mice; and inhibition of ex vivo arachidonic-acid-induced, but not ADP-induced, rat platelet aggregation. MDL 19301 and MDL 16,861 are unexpectedly weak antipyretic agents in rats.