西托溴铵
中文名称 | 西托溴铵 |
---|---|
中文同义词 | 西托溴铵;溴化N-(环丙基甲基)东莨菪碱;化合物 T14966 |
英文名称 | Cimetropium bromide |
英文同义词 | da3177;CIMETROPIUM BROMIDE;Cimetronin bromide;Cimetropium;Cimetropiumbromid;DA-3177:Alginor;N-Cyclopropvlmethylscopolamine bromide;(7(S)-(1alpha,2beta,4beta,5alpha,7beta))-9-(Cyclopropylmethyl)-7-(3-hydroxy-1-oxo-2-phenylpropoxy)-9-methyl-3-oxa-9-azoniatricyclo(3.3.1.0(sup 2,4))nonane bromide |
CAS号 | 51598-60-8 |
分子式 | C21H28BrNO4 |
分子量 | 438.36 |
EINECS号 | 641-412-6 |
相关类别 | 肌肉松弛药;麻醉用药;药物 |
Mol文件 | 51598-60-8.mol |
结构式 |
西托溴铵 性质
熔点 | 174° |
---|---|
比旋光度 | D20 -18.3° (c = 3) |
储存条件 | Hygroscopic, -20°C Freezer, Under inert atmosphere |
溶解度 | DMSO(少许)、甲醇(少许)、水(少许) |
形态 | 固体 |
颜色 | 白色 |
mAChR
Cimetropium Bromide behaves as a competitive antagonist of muscarinic-mediated contractions in isolated colonic preparations from both species, with affinity values (pA2) ranging between 7.41 and 7.82. Cimetropium has potent antimuscarinic effect in inhibition of contraction of longitudinal muscle preparations. In the superfusion experiments of the preparation which has been preloaded with labelled choline, Cimetropium decreases the labelled ACh release induced by electrical field stimulation under the muscarinic autoinhibition blocked-condition.
When administered intravenously to conscious dogs provided with a colonic Thiry fistula, Cimetropium is a potent inhibitor of large bowel motility evoked by both exogenous and endogenous stimuli. Cimetropium Bromide (10-100 μg/kg) counteracts colonic motor response to neostigmine administration with an ID 50 of 27.9 μg/kg; both tonic and phasic components of contractile response are affected. In a comparable range of doses (3-100μg/kg), the drug inhibits motor activity elicited by intraluminal distension.
安全信息
西托溴铵 化学药品说明书
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024/08/19 | HY-U00106 | 西托溴铵 Cimetropium Bromide | 51598-60-8 | 1 mg | 350元 |
2024/08/19 | HY-U00106 | 西托溴铵 Cimetropium Bromide | 51598-60-8 | 5mg | 650元 |