2-萘乙烯基酮
中文名称 | 2-萘乙烯基酮 |
---|---|
中文同义词 | 2-萘乙烯基酮;2'-萘丙烯酮;1-(萘-2-基)丙-2-烯-1-酮;化合物 T23564 |
英文名称 | ZM 449829 |
英文同义词 | 2-NAPHTHYLVINYL KETONE;1-(2-NAPHTHALENYL)-2-PROPEN-1-ONE;JAK3 INHIBITOR V;2-Propen-1-one, 1-(2-naphthalenyl)-;1-Naphthalen-2-yl-propenone;1-(2-Naphthyl)-2-propen-1-one;2'-Acrylonaphthone;ZM 449829 |
CAS号 | 4452-06-6 |
分子式 | C13H10O |
分子量 | 182.22 |
EINECS号 | |
相关类别 | 有机化学;Intracellular Signaling |
Mol文件 | 4452-06-6.mol |
结构式 |
2-萘乙烯基酮 性质
沸点 | 319.3±15.0 °C(Predicted) |
---|---|
密度 | 1.093±0.06 g/cm3(Predicted) |
储存条件 | Keep in dark place,Sealed in dry,Store in freezer, under -20°C |
溶解度 | 溶于氯仿、二氯甲烷、乙酸乙酯、DMSO、丙酮等。 |
形态 | 白色蜡状固体 |
JAK3 6.8 (pIC 50 ) |
JAK1 4.7 (pIC 50 ) |
EGFR 5.0 (pIC 50 ) |
ZM 449829 (compound 22) is a very weak inhibitors of EGF-R (pIC
50
=5.0) , Jak1 (pIC
50
=4.7), and tyrosine kinases Lck and CDK4 (pIC
50
<5.0).
ZM449829 (1 μM; 30 minutes) blocks IL-2-induced STAT5 phosphorylation.
Western Blot Analysis
Cell Line: | YTS, NK92, and ex vivo NK cells |
Concentration: | 1 μM |
Incubation Time: | 30 minutes pretreatment |
Result: | Inhibits the phosphorylation of STAT5. |